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Acta Neuropathologica Communications

Featured video: Another mechanism for the initiation and progression of Parkinson's disease

 

A research team in the USA and China identifies a potential disease mechanism in the initiation and development of Parkinson’s disease. 

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1. Content Type:Research

     |  20 February 2018

   Cooperative p16 and p21 action protects female astrocytes from transformation

   Authors:Najla Kfoury, Tao Sun, Kwanha Yu, Nathan Rockwell, Kelsey L. Tinkum, Zongtai Qi, Nicole M. Warrington, Peter McDonald, Anuradha Roy, Scott J. Weir, Carrie A. Mohila, Benjamin Deneen and Joshua B. Rubin
2. Content Type:Research

     |  20 February 2018

   Familial human prion diseases associated with prion protein mutations Y226X and G131V are transmissible to transgenic mice expressing human prion protein

   Authors:Brent Race, Katie Williams, Andrew G. Hughson, Casper Jansen, Piero Parchi, Annemieke J. M. Rozemuller and Bruce Chesebro
3. Content Type:Research

     |  20 February 2018

   Diffuse microvascular C5b-9 deposition is a common feature in muscle and nerve biopsies from diabetic patients

   Authors:Paul C. Yell, Dennis K. Burns, Evan G. Dittmar, Charles L. White III and Chunyu Cai
4. Content Type:Research

     |  15 February 2018

   Brain region-specific enhancement of remyelination and prevention of demyelination by the CSF1R kinase inhibitor BLZ945

   Authors:Nicolau Beckmann, Elisa Giorgetti, Anna Neuhaus, Stefan Zurbruegg, Nathalie Accart, Paul Smith, Julien Perdoux, Ludovic Perrot, Mark Nash, Sandrine Desrayaud, Peter Wipfli, Wilfried Frieauff and Derya R. Shimshek
5. Content Type:Research

     |  15 February 2018

   Exosomes taken up by neurons hijack the endosomal pathway to spread to interconnected neurons

   Authors:Juan Carlos Polanco, Chuanzhou Li, Nela Durisic, Robert Sullivan and Jürgen Götz

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Featured article: Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson’s disease?

Professor Zhang et al investigate the mechanism of extracellular vesicle transmission across the blood-brain barrier as it relates to Parkinson's Disease.

Featured article: Novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson’s disease

Dr. Finkelstein et al report the preclinical characterization of PBT434, a novel quinazolinone compound bearing a moderate affinity metal-binding motif, which is in development for Parkinsonian conditions.