It's not just diet and physical activity; your genes also determine how easily you lose or gain weight. In a study published in the January issue of Nature Genetics, researchers at the Icahn School of Medicine at Mount Sinai and other institutions of the Genetic Investigation of Anthropometric Traits consortium found 13 genes that carry variations associated with body mass index.
Gene expression is regulated by histone modifications, which are post-translational modifications. The most modified histone is histone H3. Post-translational modifications to histones – called marks – regulate gene expression by arranging the genome into active euchromatin regions or inactive heterochromatin regions
From the time of Hippocrates, physicians have suspected a link between epilepsy and depression. Now, for the first time, scientists at Rutgers University-New Brunswick and Columbia University have found evidence that seizures and mood disorders such as depression may share the same genetic cause in some people with epilepsy, which may lead to better screening and treatment to improve patients' quality of life.
During early 2000, professors Weinberg and Hanahan proposed that cells acquire distinctive capabilities when they advance towards a neoplastic state1. These were called hallmarks of cancer and created a useful framework to gain insights into tumor pathogenesis.
Prostate tumors tend to be what scientists call "indolent" - so slow-growing and self-contained that many affected men die with prostate cancer, not of it. But for the percentage of men whose prostate tumors metastasize, the disease is invariably fatal.
Keio University Global Research Institute, Tokyo publishes the January 2018 issue of KGRI Research Frontiers that includes researcher video profiles of Keio University researchers and research highlights from high impact publications including 'Regenerative medicine needs collaboration in and out of science in order to face current and future challenges; ‘Does eating fish protect you from depression?’; ‘Insights into the molecular mechanisms...
Mood disorders, including depression, are the most common comorbid conditions in individuals with epilepsy, but the cause remains unclear, according to a latest study by researchers at Columbia University's Mailman School of Public Health and Rutgers University.
An international team, led by researchers at the University of California San Diego School of Medicine, has developed and validated a genetic tool for predicting age of onset of aggressive prostate cancer, a disease that kills more than 26,000 American men annually.
Six novel chromosomal regions identified by scientists leading a large, prospective study of children at risk for type 1 diabetes will enable the discovery of more genes that cause the disease and more targets for treating or even preventing it.
The field of immunotherapy - the harnessing of patients' own immune systems to fend off cancer - is revolutionizing cancer treatment today. However, clinical trials often show marked improvements in only small subsets of patients, suggesting that as-yet unidentified variations among tumors result in distinct paths of disease progression and response to therapy.
A new study published in PLOS Pathogens revealed the role of genetic variations between different strains of the same bacterial species in inducing variations in immune system responses. Former studies have shown that susceptibility to infection with the same species of disease causing bacteria may vary among people.
Intrauterine growth restriction (IUGR) is a condition in which the baby does not grow properly during its time in the mother’s womb. It is due to a mix of factors including disease conditions in the mother, genetic defects in the baby, and poor placental growth.
Scientists at the Centre for Research in Agricultural Genomics (CRAG) in Spain have identified the members of a protein family linked with the internal clocks of plants that act sequentially to restrict plant growth until just before daylight, according to a new study published in the journal Current Biology.
Mount Sinai Researchers have just discovered that patients in the Ashkenazi Jewish population with Crohn's disease (a chronic inflammatory of the digestive system) are more likely to carry the LRRK2 gene mutation.
Mutated RAS genes are some of the most common genetic drivers of cancer, especially in aggressive cancers like pancreatic and lung cancer, but no medicines that target RAS are available despite decades of effort.
A groundbreaking report, led by Professor Mark Lawler, Chair in Translational Cancer Genomics at Queen's University Belfast highlights a plan to end bowel cancer, the second most common cause of cancer death in Europe.
Researchers at Carnegie Mellon University have developed a new dynamic statistical model to visualize changing patterns in networks, including gene expression during developmental periods of the brain.
ChIP is an effective technique used for specifically matching histone or protein modifications to the genomic regions. After isolating chromatin, antibodies to the antigen concerned are used to establish whether this target attaches to a specific DNA sequence or not, or to alternatively map the distribution across the genome (DNA or microarray sequencing). This can be carried out either temporally or spatially.
Introduction This article describes chromatin fragmentation, cross-linking, ChIP antibodies, and draws a comparison between X-ChIP and N-ChIP techniques. What is ChIP? The ChIP follows a simple principle - the selective enrichment of a chromatin percentage comprising of a specific protein. A target protein along with its relevant DNA is immunoprecipitated with an antibody.
A new study reveals how dengue virus manages to reproduce itself in an infected person without triggering the body's normal defenses. Duke researchers report that dengue pulls off this hoax by co-opting a specialized structure within host cells for its own purposes, like a lazy roommate sneaking bits of his laundry into the communal wash.
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