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Investigation of Pneumonic Plague, Madagascar - Volume 24, Number 1—January 2018 - Emerging Infectious Disease journal - CDC

Investigation of Pneumonic Plague, Madagascar - Volume 24, Number 1—January 2018 - Emerging Infectious Disease journal - CDC

Volume 24, Number 1—January 2018


Investigation of Pneumonic Plague, Madagascar

To the Editor: In an investigation of a pneumonic plague outbreak in Madagascar, Ramasindrazana et al. reported isolation of Yersinia pestis from 2 patients and seroconversion in 2 additional patients; these data indicated 4 (28.7%) of 14 diagnosed cases among described cases (1). The risk for overestimation of pneumonic plague contagion was illustrated by an outbreak in the Democratic Republic of the Congo that included cases of leptospirosis (2). In fact, thorough investigations in Uganda indicated that 2 index patients transmitted Y. pestisto only 1 caregiver each and none to 23 additional untreated close contacts (3). Another investigation in China showed that 3 index patients exposed 214 contacts during 3–13 days; all contacts were quarantined, and no secondary cases were reported (4). Transmission of Y. pestis by respiratory droplets requires face-to-face exposure with a coughing patient, as can occur during funerals by close contact with coughing persons who may have been exposed to the pathogen while visiting or attending the patient before he or she died. Therefore, the threat for plague epidemics fueled by pneumonic plague can be reduced by measures such as isolating patients and wearing a mask when exposure is likely (5).
We propose the hypothesis that only the transmission of Y. pestis by ectoparasites, such as lice and fleas, by close contact with infected humans can sustain outbreaks and epidemics. In plague-endemic regions, to support the appropriate management of patients and provide a rapid and accurate microbiological diagnosis, we recommend point-of-care laboratories, some of which are now operating in a few remote regions of Africa. In addition to direct diagnosis of disease in humans, direct detection of Y. pestis at the point-of-care in potential sources and vectors would facilitate understanding of how plague epidemics sustain.
Michel DrancourtComments to Author  and Didier Raoult
Author affiliations: MEPHI, UMR, IRD, Aix-Marseille Université, Marseille, France


  1. Ramasindrazana BAndrianaivoarimanana VRakotondramanga JMBirdsell DNRatsitorahina MRajerison MPneumonic plague transmission, Moramanga, Madagascar, 2015. Emerg Infect Dis2017;23:5214DOIPubMed
  2. Bertherat EMueller MJShako JCPicardeau MDiscovery of a leptospirosis cluster amidst a pneumonic plague outbreak in a miners’ camp in the Democratic Republic of the Congo. Int J Environ Res Public Health2014;11:182433DOIPubMed
  3. Begier EMAsiki GAnywaine ZYockey BSchriefer MEAleti Pet al. Pneumonic plague cluster, Uganda, 2004. Emerg Infect Dis2006;12:4607DOIPubMed
  4. Li YFLi DBShao HSLi HJHan YDPlague in China 2014-All sporadic case report of pneumonic plague. BMC Infect Dis2016;16:85DOIPubMed
  5. Ratsitorahina MChanteau SRahalison LRatsifasoamanana LBoisier PEpidemiological and diagnostic aspects of the outbreak of pneumonic plague in Madagascar. Lancet2000;355:1113DOIPubMed
Cite This Article

DOI: 10.3201/eid2401.170760

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