Revised text to state that the incidence of atypia and ductal carcinoma in situ breast lesions has increased over the past three decades as a result of widespread mammography screening, although atypia is generally mammographically occult.
Revised text to state that because the extent of these biases is never clear in any particular study, the gold standard used by most groups to assess the benefits of screening is the randomized controlled trial (RCT) with cause-specific mortality as the endpoint. Also added text to state that RCTs with cause-specific mortality as the endpoint avoid lead/length/overdiagnosis bias.
Added text to state that it is also important to recognize that the harms of screening, especially false-positive results, are greater with a first screen and decrease with subsequent screens, for which there are previous images for comparison.
Revised text to state that currently, physicians cannot confidently distinguish cancers that will cause illness and/or death from those that will remain occult, so cancers are treated in almost all cases.
ver historia personal en: www.cerasale.com.ar [dado de baja por la Cancillería Argentina por temas políticos, propio de la censura que rige en nuestro medio]//
weblog.maimonides.edu/farmacia/archives/UM_Informe_Autoevaluacion_FyB.pdf - //
weblog.maimonides.edu/farmacia/archives/0216_Admin_FarmEcon.pdf - //
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