PARP Inhibitors in Ovarian Cancer Treatment
N Engl J Med 2016; 375:2197-2198December 1, 2016DOI: 10.1056/NEJMe1612843
This article has no abstract; the first 100 words appear below.
A paradox of DNA biology is that sequence integrity must be maintained in order for the organism to maintain life and normal functions, yet evolution requires some variability in gene expression so that changes that are more adaptive are positively selected. Indeed, more highly evolved species have developed an immune system that protects organisms against the world of dangers as a direct consequence of focusing DNA mutation on a particular subset of genes that encode for antigen receptors. However, in general, environmental and biologic insults that disrupt the DNA sequence (and there are many of these, including ultraviolet light, mutagens . . .
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From the Division of Solid Tumor Oncology, Memorial Sloan Kettering Cancer Center, New York (D.R.S.).
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