Attainment of LDL Cholesterol Treatment Goals in Children and Adolescents With Familial Hypercholesterolemia. The SAFEHEART Follow-up Registry. - PubMed - NCBI
Attainment of LDL Cholesterol Treatment Goals in Children and Adolescents With Familial Hypercholesterolemia. The SAFEHEART Follow-up Registry.
[Article in English, Spanish]
Saltijeral A1,
Pérez de Isla L2,
Alonso R3,
Muñiz O4,
Díaz-Díaz JL5,
Fuentes F6,
Mata N7,
de Andrés R8,
Díaz-Soto G9,
Pastor J10,
Pinilla JM11,
Zambón D12,
Pinto X13,
Badimón L14,
Mata P15;
SAFEHEART Investigators.
Abstract
INTRODUCTION AND OBJECTIVES:
Little is known about the characteristics of persons with familial hypercholesterolemia (FH) younger than 18 years, the lipid-lowering therapy used in these patients, and the lipid goals reached in real life. Our aim was to evaluate the achievement of low-density lipoprotein cholesterol (LDL-C) treatment goals in FH patients younger than 18 years enrolled in a large national registry.
METHODS:
We analyzed patients younger than 18 years enrolled in a large ongoing registry of molecularly-defined patients with FH in Spain. The attainment of guideline-recommended plasma LDL-C goals at entry and follow-up was analyzed in relation to the use of lipid-lowering therapy.
RESULTS:
We enrolled 392 individuals younger than 18 years. Of these, 217 were molecularly-diagnosed FH patients and had a complete follow-up. The median follow-up time was 4.69 years (interquartile range, 2.48-6.38 years), 68.2% of FH patients were on statins, and 41.5% patients had LDL-C < 130mg/dL. Statin use was the only predictor of LDL-C goal attainment.
CONCLUSIONS:
This study shows that a high proportion of FH patients younger than 18 years have high LDL-C levels and fail to achieve recommended LDL-C targets. Statin use was the only independent predictor of LDL-C goal achievement. No safety concerns were detected during follow-up. These results indicate that many FH patients are not adequately controlled and that there is still room for treatment improvement.
Copyright © 2016 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.
KEYWORDS:
Adolescentes; Adolescents; Cardiovascular disease; Children; Enfermedad cardiovascular; Estatinas; Familial hypercholesterolemia; Hipercolesterolemia familiar; Lipid-lowering therapy; Low-density lipoprotein cholesterol goals; Niños; Objetivos de colesterol unido a lipoproteínas de baja densidad; Statins; Terapia hipolipemiante
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