martes, 9 de agosto de 2016

Underweight Seniors May Have Added Alzheimer's Risk: MedlinePlus

Underweight Seniors May Have Added Alzheimer's Risk: MedlinePlus

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Underweight Seniors May Have Added Alzheimer's Risk

Study links lower body weight to increased amounts of disease-causing plaque in the brain
By Robert Preidt
Friday, August 5, 2016
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FRIDAY, Aug. 5, 2016 (HealthDay News) -- Having a lower weight may increase older adults' risk of the memory-robbing disorder Alzheimer's disease, new research suggests.
The study included 280 healthy people aged 62 to 90 with normal mental function. The participants underwent physical exams, genetic testing and brain scans.
According to the researchers from Brigham and Women's Hospital and Massachusetts General Hospital in Boston, there was a link between lower body weight and more extensive deposits of Alzheimer's-related beta-amyloid protein in the brain.
This link was particularly strong in people with the APOE4 gene variant, which is known to increase the risk of Alzheimer's, the study authors reported.
"Elevated cortical amyloid is believed to be the first stage of the preclinical form of Alzheimer's disease, so our findings suggest that individuals who are underweight late in life may be at greater risk for this disease," senior study author Dr. Gad Marshall said in a joint hospital news release. Marshall is a neurologist at Brigham and Women's and Mass General, and is also an assistant professor of neurology at Harvard Medical School.
"Finding this association with a strong marker of Alzheimer's disease risk reinforces the idea that being underweight as you get older may not be a good thing when it comes to your brain health," he added.
The association seen in the study doesn't prove a cause-and-effect relationship. Further research is needed to learn more about the connection between lower body weight and increased amyloid levels, the investigators noted.
"A likely explanation for the association is that low BMI (body mass index) is an indicator for frailty -- a syndrome involving reduced weight, slower movement and loss of strength that is known to be associated with Alzheimer's risk," Marshall said.
The study was published Aug. 3 in the Journal of Alzheimer's Disease.
SOURCE: Brigham and Women's Hospital, Massachusetts General Hospital, news release, Aug. 2, 2016
News stories are provided by HealthDay and do not reflect the views of MedlinePlus, the National Library of Medicine, the National Institutes of Health, the U.S. Department of Health and Human Services, or federal policy.
More Health News on:
Alzheimer's Disease
Body Weight
Seniors' Health

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