Current Highlight from August 12, 2016
Silver Nanoparticle Effects on Intestinal Permeability
NCTR scientists demonstrated a dose-dependent increase in intestinal permeability in an in vitro model of human colonic epithelial cells treated with 10 nm silver nanoparticles (AgNPs). However, no effects were observed when treated with 20, 75, or 110 nm AgNPs. At the 10 nm size, AgNPs were detected within cells and silver was able to pass through the epithelial cell monolayer, thus indicating both penetration of AgNPs into cells and passage of AgNPs or derivatives through the epithelial barrier. Additionally, exposure to 10 nm AgNPs resulted in the upregulation of genes involved in maintaining the epithelial barrier, possibly indicating an attempt to compensate for increased permeability. The results of this study suggest that gastrointestinal exposure to small-size AgNPs could potentially compromise the integrity of the intestinal epithelium and disrupt barrier function which could have health consequences for the gastrointestinal tract. This study is currently available online at Journal of Nanobiotechnology
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.For additional information, please contact Sangeeta Khare, Ph.D., Division of Microbiology, FDA/NCTR.
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870-543-7000National Center for Toxicological ResearchFood and Drug Administration3900 NCTR RoadJefferson, AR 72079
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