NCI Visuals Online: Image Details
Measuring Delivery of Porous Silica Nanoparticles with Ex Ovo Chick Embryo Models
Researchers at the University of New Mexico Cancer Nanotechnology Platform Partnership (CNPP) and Cancer Nanoscience and Microsystems Training Center (CNTC) are developing new nanoparticle platforms for targeted cellular delivery of multicomponent cargos and observing their interaction with cells in vivo. In this image, porous silica nanoparticles loaded with fluorescent cargo are visible circulating in the vasculature or arrested in the chorioallantoic membrane (CAM) of ex ovo chick embryos. Particles of different size, shape, and surface chemistry are observed as different colors, with particle path and velocity determined via fluorescent trails. Blue and black are tissue and red blood cells, respectively.