Recognition of genetic predisposition in pediatric cancer patients: An easy-to-use selection tool. - PubMed - NCBI
Eur J Med Genet. 2016 Jan 26. pii: S1769-7212(16)30008-8. doi: 10.1016/j.ejmg.2016.01.008. [Epub ahead of print]
Recognition of genetic predisposition in pediatric cancer patients: An easy-to-use selection tool.
Abstract
Genetic predisposition for childhood cancer is under diagnosed. Identifying these patients may lead to therapy adjustments in case of syndrome-related increased toxicity or resistant disease and syndrome-specific screening programs may lead to early detection of a further independent malignancy. Cancer surveillance might also be warranted for affected relatives and detection of a genetic mutation can allow for reproductive counseling. Here we present an easy-to-use selection tool, based on a systematic review of pediatric cancer predisposing syndromes, to identify patients who may benefit from genetic counseling. The selection tool involves five questions concerning family history, the type of malignancy, multiple primary malignancies, specific features and excessive toxicity, which results in the selection of those patients that may benefit from referral to a clinical geneticist. Copyright © 2016. Published by Elsevier Masson SAS.
KEYWORDS:
Cancer susceptibility; childhood cancer; congenital anomalies; dysmorphisms; family history; selection tool
- PMID:
- 26825391
- [PubMed - as supplied by publisher]
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