domingo, 28 de febrero de 2016

Implementation of the 21-gene recurrence score test in the United States in 2011. - PubMed - NCBI

Implementation of the 21-gene recurrence score test in the United States in 2011. - PubMed - NCBI



 2016 Feb 18. doi: 10.1038/gim.2015.218. [Epub ahead of print]

Implementation of the 21-gene recurrence score test in the United States in 2011.

Abstract

PURPOSE:

We examined hospital use of the 21-gene breast cancer test in the United States. We report state-level differences in utilization and propose a model for predicting implementation of guideline-recommended genomic testing.

METHODS:

Genomic Health provided test orders for calendar year 2011.We summarized utilization at the hospital and state levels. Using logistic regression, we analyzed the association between the likelihood to order the test and the hospital's institutional and regional characteristics.

RESULTS:

In 2011, 45% of 4,712 acute-care hospitals ordered the test, which suggests that 25% of newly diagnosed invasive female breast cancer cases were tested. Significant predictors of testing included participation in National Cancer Institute (NCI) clinical research cooperative groups (odds ratio (OR) 3.73; 95% confidence interval, 2.96-4.70), advanced imaging (OR, 2.19; CI, 1.78-2.68), high-complexity laboratory (OR, 2.15; CI, 1.24-3.70), affiliation with a medical school (OR, 1.57; CI, 1.31-1.88), and reconstructive surgery (OR, 1.23; CI, 1.01-1.50). Significant regional predictors included metropolitan county (OR, 3.77; CI, 2.83-5.03), above-mean income (OR, 1.37; CI, 1.11-1.69), and education (OR, 1.26; CI, 1.03-1.54). Negative predictors included designation as a critical-access hospital (OR, 0.10; CI, 0.07-0.14) and distance from an NCI cancer center (OR, 0.998; CI, 0.997-0.999), with a 15% decrease in likelihood for every 100 miles.

CONCLUSION:

Despite considerable market penetration of the test, there are significant regional and site-of-care differences in implementation, particularly in rural states.Genet Med advance online publication 18 February 2016Genetics in Medicine (2016); doi:10.1038/gim.2015.218.

PMID:
 
26890451
 
[PubMed - as supplied by publisher]

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