Occupational Exposure to Dromedaries and Risk for MERS-CoV Infection, Qatar, 2013–2014 - Volume 21, Number 8—August 2015 - Emerging Infectious Disease journal - CDC
Volume 21, Number 8—August 2015
Dispatch
Occupational Exposure to Dromedaries and Risk for MERS-CoV Infection, Qatar, 2013–2014
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Chantal B.E.M. Reusken1 , Elmoubasher A.B.A. Farag1, Bart L. Haagmans1, Khaled A. Mohran1, Gert-Jan Godeke, Stalin Raj, Farhoud Alhajri, Salih A. Al-Marri, Hamad E. Al-Romaihi, Mohamed Al-Thani, Berend-Jan Bosch, Annemiek A. van der Eijk, Ahmed M. El-Sayed, Adel K. Ibrahim, N. Al-Molawi, Marcel A. Müller, Syed K. Pasha, Christian Drosten, Mohd M. AlHajri, and Marion P.G. Koopmans
Abstract
We determined the presence of neutralizing antibodies to Middle East respiratory syndrome coronavirus in persons in Qatar with and without dromedary contact. Antibodies were only detected in those with contact, suggesting dromedary exposure as a risk factor for infection. Findings also showed evidence for substantial underestimation of the infection in populations at risk in Qatar.
Since Middle East respiratory syndrome coronavirus (MERS-CoV) was first detected in 2012, approximately 1,000 human infections have been reported to the World Health Organization, all linked to residence in or travel to countries on the Arabian Peninsula (1). Dromedaries (Camelus dromedarius) are thought to play a central role in MERS epidemiology because widespread evidence of MERS-CoV–specific antibodies and virus shedding in camels was found (2), and highly similar viruses have been detected in humans and dromedaries at the same location (3,4). These data suggest a direct zoonotic risk for MERS-CoV infection among persons in contact with camels. We describe a comparative serologic investigation in Qatar among persons with and without daily occupational exposure to dromedaries.
Dr. Reusken is a public health virologist at the Viroscience department of Erasmus Medical Center. Her research interests include viruses operating at the animal–human interface.
Acknowledgment
We are indebted to Benjamin Meyer for excellent technical assistance. We are grateful to the Joint Supreme Council of Health and Animal Resources Department of Ministry of Environment field investigation team for exceptional research assistance, in particular H. Gobashy and M. El-Maghraby, and to the Doha Camel slaughterhouse veterinarians, staff, and workers for their help. We also thank Ashraf Ayad, Ahmed Salem, Tarik Mosaad Ali al-sharbeeni, Thomas P. Samuel, Redentor Cuizon, Ronald R. Manaor, Khalid Yousif, and Farid Abdoudia for help with collecting samples in the field.
References
- World Health Organization. Disease outbreak news. Middle East respiratory syndrome coronavirus (MERS-CoV)—Qatar. 2015 Mar 11 [cited 2015 Mar 19]. http://www.who.int/csr/don/11-march-2015-mers-qatar/en/
- Mackay IM, Arden KE. Middle East respiratory syndrome: an emerging coronavirus infection tracked by the crowd. Virus Res. 2015 [cited 2015 Mar 18]. Epub 2015 Feb 2.
- Haagmans BL, Al Dhahiry SH, Reusken CB, Raj VS, Galiano M, Myers R, Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation. Lancet Infect Dis. 2014;14:140–5. DOIPubMed
- Memish Z, Cotton M, Meyer B, Watson S, Alsahafi A, Al Rabeeah A, Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia, 2013. Emerg Infect Dis. 2014;20:1012–5 . DOIPubMed
- Reusken CB, Haagmans BL, Muller MA, Gutierrez C, Godeke GJ, Meyer B, Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study. Lancet Infect Dis. 2013;13:859–66 . DOIPubMed
- Reusken C, Mou H, Godeke GJ, van der Hoek L, Meyer B, Muller MA, Specific serology for emerging human coronaviruses by protein microarray.Euro Surveill. 2013;18:20441 .PubMed
- Müller MA, Meyer B, Corman VM, Al-Masri M, Turkestani A, Ritz D, Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study. Lancet Infect Dis. 2015;15:559–64 . DOIPubMed
- Hemida MG, Al-Naeem A, Perera RAPM, Chin AWH, Poon LLM, Peiris M. Lack of Middle East respiratory syndrome coronavirus transmission from infected camels. Emerg Infect Dis. 2015;21:699–701 . DOIPubMed
- Memish ZA, Alsahly A, Masri MA, Heil GL, Anderson BD, Peiris M, Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012. Influenza Other Respir Viruses. 2015;9:64–7.
- Aburizaiza AS, Mattes FM, Azhar EI, Hassan AM, Memish ZA, Muth D, Investigation of anti-middle East respiratory syndrome antibodies in blood donors and slaughterhouse workers in Jeddah and Makkah, Saudi Arabia, fall 2012. J Infect Dis. 2014;209:243–6. DOIPubMed
- Chu DK, Poon LL, Gomaa MM, Shehata MM, Perera RA, Abu Zeid D. MERS coronaviruses in dromedary camels, Egypt. Emerg Infect Dis.2014;20:1049–53. DOIPubMed
- Pinschewer DD, Perez M, Jeetendra E, Bachi T, Horvath E, Hengartner H, Kinetics of protective antibodies are determined by the viral surface antigen. J Clin Invest. 2004;114:988–93. DOIPubMed
- Buchy P, Vong S, Chu S, Garcia JM, Hien TT, Hien VM, Kinetics of neutralizing antibodies in patients naturally infected by H5N1 virus. PLoS ONE.2010;5:e10864 and. DOIPubMed
- Farrington CP. Modelling forces of infection for measles, mumps and rubella. Stat Med. 1990;9:953–67 . DOIPubMed
- Paull SH, Song S, McClure KM, Sackett LC, Kilpatrick AM, Johnson PT. From superspreaders to disease hotspots: linking transmission across hosts and space. Front Ecol Environ. 2012;10:75–82 . DOIPubMed
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Suggested citation for this article: Reusken CBEM, Farag EABA, Haagmans BL, Mohran KA, Godeke G-J, Raj VS, et al. Occupational exposure to dromedaries and risk for MERS-CoV infection, Qatar, 2013–2014. Emerg Infect Dis. 2015 Aug [date cited]. http://dx.doi.org/10.3201/eid2108.150481
1These first authors contributed equally to this article.
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