Drug Resistance–Associated Mutations in Mycoplasma genitalium in Female Sex Workers, Japan - Volume 21, Number 6—June 2015 - Emerging Infectious Disease journal - CDC
Volume 21, Number 6—June 2015
Drug Resistance–Associated Mutations in Mycoplasma genitalium in Female Sex Workers, Japan
For Mycoplasma genitalium infections, azithromycin regimens have been considered first-line treatments, and fluoroquinolone regimens, including those of moxifloxacin and sitafloxacin, have been effective second-line treatments (1). However, the proportion of M. genitalium harboring macrolide or fluoroquinolone resistance–associated mutations has been increasing in male and female patients with M. genitalium infections (2–5), and treating M. genitalium infections with current antimicrobial chemotherapies is increasingly difficult (5,6).
The prevalence of M. genitalium infections in women at low risk for sexually transmitted infections (STIs) is reportedly 2.0%, with the range for most cohorts being <1%–5%. In high-risk populations, the prevalence is 0%–42% (7). For female sex workers (FSWs), the range of M. genitalium prevalence rates is reportedly 12%–26% (7–10). FSWs could be a reservoir of M. genitalium infections, but little is known about drug resistance in M. genitalium in FSWs.
In this study, vaginal swab and throat washing samples collected from 149 FSWs were examined for the presence of M. genitalium. Positive specimens were then tested for drug resistance–associated mutations in the M. genitalium DNA.
Dr. Deguchi is a professor of urology at the Graduate School of Medicine, Gifu University, Gifu City, Japan. His research interests involve the pathogenic roles of genital mycoplasmas in urogenital infections and the management of patients with urogenital infections.
We thank Central Lab Services, LSI Medience Corporation, Tokyo, Japan, for its technical support.
This work was supported in part by the Japan Society for the Promotion of Science, Tokyo, Japan (Grant-in-Aid for Scientific Research [C] 25462509).
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Suggested citation for this article: Deguchi T, Yasuda M, Horie K, Seike K, Kikuchi M, Mizutani K, et al. Drug resistance–associated mutations inMycoplasma genitalium in female sex workers, Japan. Emerg Infect Dis. 2015 Jun [date cited]. http://dx.doi.org/10.3201/eid2106.142013