Severe Fever with Thrombocytopenia Syndrome, Shandong Province, China, 2011 - Volume 20, Number 1—January 2014 - Emerging Infectious Disease journal - CDC
Volume 20, Number 1—January 2014
Severe Fever with Thrombocytopenia Syndrome, Shandong Province, China, 2011
Hong-Ling Wen1, Li Zhao1, Shenyong Zhai, Yuanyuan Chi, Feng Cui, Dongxu Wang, Ling Wang, Zhiyu Wang, Qian Wang, Shoufeng Zhang, Yan Liu, Hao Yu, and Xue-Jie Yu
Author affiliations: Shandong University School of Public Health, Jinan, China (H.-L. Wen. L. Zhao, Y. Chi, D. Wang, Z. Wang, X.-J. Yu); Zibo Municipal Center for Disease Control and Prevention, Zibo, China (S. Zhai, F. Cui, L. Wang); Yiyuan County Center for Disease Control and Prevention, Yiyuan, China (Q. Wang, S. Zhang); University of Texas Medical Branch, Galveston, Texas, USA (Y. Liu, H. Yu, X.-J. Yu)
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that was identified in 2009 in rural areas in China. This disease is caused by SFTS virus (SFTSV), a novel bunyavirus in the family Bunyaviridae, genus Phlebovirus. (1). Fatal cases of infection with SFTSV have been recently reported in Japan and South Korea (2,3).
SFTS is a severe disease and has had a case-fatality rate of 12%–30% in China (1). The major manifestations of SFTS are fever, thrombocytopenia, leukopenia, and increased serum levels of hepatic aminotransferases. SFTSV has been detected in ticks and might be transmitted by them (1,4). Occasionally, the disease can also be transmitted from person to person through contact with infected blood or mucus (5–9).
The epidemiologic and clinical characteristics of SFTSV infection are not well defined. Approximately 30% of clinically diagnosed cases of SFTS cannot be confirmed by laboratory tests (1,10), and clinicians may confuse this disease with diseases caused by other pathogens. Therefore, to obtain information on clinical and laboratory characteristics of this disease, with a focus on diagnosis, we used acute-phase and convalescent-phase serum samples from 24 patients given a clinical diagnosis of SFTS in Yiyuan County, Shandong Province, China, an area to which SFTSV is endemic (11),