Gynecol Oncol. 2013 Dec 12. pii: S0090-8258(13)01373-5. doi: 10.1016/j.ygyno.2013.12.009. [Epub ahead of print]
Outcome of unexpected adnexal neoplasia discovered during risk reduction salpingo-oophorectomy in women with germ-line BRCA1 or BRCA2 mutations.
Conner JR1, Meserve E1, Pizer E2, Garber J3, Roh M4, Urban N5, Drescher C6, Quade BJ1, Muto M7, Howitt BE1, Pearlman MD8, Berkowitz RS7, Horowitz N7,Crum CP9, Feltmate C7.
This study computed the risk of clinically silent adnexal neoplasia in women with germ-line BRCA1 or BRCA2 mutations (BRCAm+) and determined recurrence risk.
We analyzed risk reduction salpingo-oophorectomies (RRSOs) from 349 BRCAm+ women processed by the SEE-FIM protocol and addressed recurrence rates for 29 neoplasms from three institutions.
Nineteen neoplasms (5.4%) were identified at one institution, 9.2% of BRCA1 and 3.4% of BRCA2 mutation-positive women. Fourteen had a high-grade tubal intraepithelial neoplasm (HGTIN, 74%). Mean age (54.4) was higher than the BRCAm+ cohort without neoplasia (47.8) and frequency increased with age (p< 0.001). Twenty-nine BRCAm+ patients with neoplasia from three institutions were followed for a median of 5years (1-8years.). One of 11 with HGTIN alone (9%) recurred at 4years, in contrast to 3 of 18 with invasion or involvement of other sites (16.7%). All but two are currently alive. Among the 29 patients in the three institution cohort, mean ages for HGTIN and advanced disease were 49.2 and 57.7 (p=0.027).
Adnexal neoplasia is present in 5-6% of RRSOs, is more common in women with BRCA1 mutations, and recurs in 9% of women with HGTIN alone. The lag in time from diagnosis of the HGTIN to pelvic recurrence (4years) and differences in mean age between HGTIN and advanced disease (8.5years) suggest an interval of several years from the onset of HGTIN until pelvic cancer develops. However, some neoplasms occur in the absence of HGTIN.
Copyright © 2013. Published by Elsevier Inc.
BRCA, Fallopian, Ovarian cancer, Serous cancer
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