NCI Cancer Center News
New models of drug-resistant breast cancer point to better treatments
Human breast tumors transplanted into mice are excellent models of metastatic cancer and are providing insights into how to attack breast cancers that no longer respond to the drugs used to treat them, according to research from Washington University School of Medicine (home of the Alvin J. Siteman Cancer Center) in St. Louis, presented Dec. 12 at the San Antonio Breast Cancer Symposium.
Among the research institutions NCI funds across the United States, it currently designates 68 as Cancer Centers. Largely based in research universities, these facilities are home to many of the NCI-supported scientists who conduct a wide range of intense, laboratory research into cancer’s origins and development. The Cancer Centers Program also focuses on trans-disciplinary research, including population science and clinical research. The centers’ research results are often at the forefront of studies in the cancer field.
December 12, 2013
By Julia Evangelou Strait
Matthew J. Ellis, MD, PhD, said the research, presented Dec. 12 at the San Antonio Breast Cancer Symposium, is a step toward precision medicine, allowing scientists to study tumors from patients whose treatment regimens are well-documented.
This work was funded by grants to Matthew J. Ellis by Susan G. Komen for the Cure (BCTR0707808, KG090422 and PG12220321). The DNA sequencing and analysis were performed by The Genome Institute at Washington University School of Medicine and supported by grants to Richard K. Wilson from the National Human Genome Research Institute (NHGRI U54 HG003079). The tissue procurement core was supported by NCI 3P50 CA68438. The HAMLET Core was supported by CTSA grant UL1 RR024992. The RPPA analysis was supported by PO1CA099031, U54CA112970, KG081694 and P30 CA16672 to Gordon Mills. The RNA sequencing was supported by the TCGA Project (U24-CA143848), the NCI Breast SPORE program (P50-CA58223-09A1), and by the Breast Cancer Research Foundation to Charles Perou.