Obesity, Genomics & Public Health
The merits of subtyping obesity: one size does not fit all
Alison E. Field, JAMA, Nov 27
How early should obesity prevention start?
Matthew W. Gillman et al. N Engl J Med 2013; 369:2173-2175 Dec 5
CDC information on obesity and overweight
CDC information on genomics and obesity
CDC HuGENet online teaching case study: genetic association in obesity
PHG Foundation: Genomics of obesity- Prevention and management of obesity focuses on environmental causes. As understanding of the genetic basis for obesity improves, is it time for a rethink? By Dr Louise Aston & Dr Mark Kroese (2013)
Did you know? 1604 genes have been reported in relation to obesity risks & outcomes, including 151 genomewide association studies? To find out more, visit the HuGE Navigator
The Merits of Subtyping ObesityOne Size Does Not Fit All
In the United States, approximately 70% of adults and 33% of children and adolescents are overweight or obese.1,2 Although it is widely accepted that there are a variety of genetic, behavioral, and environmental determinants, the strength of the associations of individual risk factors with obesity is only small to moderate. Other than bariatric surgery, no pharmacologic or behavioral weight loss treatments have been found to consistently result in large sustained weight losses. One reason for the lack of stronger associations with risk factors or more consistently successful treatment is that all types of overweight and obesity are often grouped together. This approach potentially obscures strong associations between risk factors and specific subtypes of obesity.