Inconsistency in large pharmacogenomic studies : Nature : Nature Publishing Group

Inconsistency in large pharmacogenomic studies : Nature : Nature Publishing Group

Inconsistency in large pharmacogenomic studies

• Benjamin Haibe-Kains,
• Nehme El-Hachem,
• Nicolai Juul Birkbak,
• Andrew C. Jin,
• Andrew H. Beck,
• Hugo J. W. L. Aerts
• & John Quackenbush

• Affiliations
• Contributions
• Corresponding author

Nature

(2013)

doi:10.1038/nature12831

Received

15 April 2013

Accepted

07 November 2013

Published online

27 November 2013

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Two large-scale pharmacogenomic studies were published recently in this journal. Genomic data are well correlated between studies; however, the measured drug response data are highly discordant. Although the source of inconsistencies remains uncertain, it has potential implications for using these outcome measures to assess gene–drug associations or select potential anticancer drugs on the basis of their reported results.

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