Inconsistency in large pharmacogenomic studies
- Nature
- doi:10.1038/nature12831
- Received
- Accepted
- Published online
Two large-scale pharmacogenomic studies were published recently in this journal. Genomic data are well correlated between studies; however, the measured drug response data are highly discordant. Although the source of inconsistencies remains uncertain, it has potential implications for using these outcome measures to assess gene–drug associations or select potential anticancer drugs on the basis of their reported results.
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