Total Synthesis and Stereochemical Assignment of Baringolin - Just-Baringo - 2013 - Angewandte Chemie International Edition - Wiley Online Library

Total Synthesis and Stereochemical Assignment of Baringolin - Just-Baringo - 2013 - Angewandte Chemie International Edition - Wiley Online Library

Total Synthesis and Stereochemical Assignment of Baringolin^†

1. Xavier Just-Baringo^1,2,


2. Dr. Paolo Bruno^1,2,


3. Dr. Lars K. Ottesen^1,2,


4. Dr. Librada M. Cañedo⁵,


5. Prof. Fernando Albericio^1,2,3,*,


6. Prof. Mercedes Álvarez^1,2,4,*

Article first published online: 18 JUN 2013

DOI: 10.1002/anie.201302372

Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Issue

Angewandte Chemie International Edition

Early View (Online Version of Record published before inclusion in an issue)

Additional Information(Show All)

How to CiteAuthor InformationPublication HistoryFunding Information

1. ^†
   
   We gratefully acknowledge support from the Spanish Science and Innovation Ministry, CICYT (CTQ2012-30930) and the Generalitat de Catalunya (2009SGR 1024). X.J. thanks ISCIII for a PFIS grant. We also thank Dr. Antonio Fernandez from Biomar SA for supplying a sample of the natural product for comparison.
   
   

• Advanced >


• Saved Searches >

ARTICLE TOOLS

• Get PDF (525K)

• Abstract


• Article


• References


• Supporting Information


• Cited By

View Full Article with Supporting Information (HTML) Get PDF (525K)

Keywords:

• antibiotics;


• cross-couplings;


• heterocycles;


• natural products;


• thiopeptides

The thiopeptide antibiotic baringolin has been synthesized, and its structure and stereochemistry have been confirmed. The use of a strategy based on palladium-catalyzed cross-couplings permitted a modular construction of this natural product.

View Full Article with Supporting Information (HTML) Get PDF (525K)