Total Synthesis and Stereochemical Assignment of Baringolin†
Article first published online: 18 JUN 2013
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
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We gratefully acknowledge support from the Spanish Science and Innovation Ministry, CICYT (CTQ2012-30930) and the Generalitat de Catalunya (2009SGR 1024). X.J. thanks ISCIII for a PFIS grant. We also thank Dr. Antonio Fernandez from Biomar SA for supplying a sample of the natural product for comparison.
- natural products;
The thiopeptide antibiotic baringolin has been synthesized, and its structure and stereochemistry have been confirmed. The use of a strategy based on palladium-catalyzed cross-couplings permitted a modular construction of this natural product.