viernes, 14 de junio de 2013

Persistence of cognitive impairment and its nega... [Psychol Med. 2013] - PubMed - NCBI

Persistence of cognitive impairment and its nega... [Psychol Med. 2013] - PubMed - NCBI

Psychol Med. 2013 Jun;43(6):1187-96. doi: 10.1017/S0033291712001948. Epub 2012 Aug 31.

Persistence of cognitive impairment and its negative impact on psychosocial functioning in lithium-treated, euthymic bipolar patients: a 6-year follow-up study.


Psychiatric Service, Hospital Santa Maria, University of Lleida, IRBLleida (Biomedicine Research Institute), Lleida, Spain.



Previous cross-sectional studies report that cognitive impairment is associated with poor psychosocial functioning in euthymic bipolar patients. There is a lack of long-term studies to determine the course of cognitive impairment and its impact on functional outcome. Method A total of 54 subjects were assessed at baseline and 6 years later; 28 had DSM-IV TR bipolar I or II disorder (recruited, at baseline, from a Lithium Clinic Program) and 26 were healthy matched controls. They were all assessed with a cognitive battery tapping into the main cognitive domains (executive function, attention, processing speed, verbal memory and visual memory) twice over a 6-year follow-up period. All patients were euthymic (Hamilton Rating Scale for Depression score lower than 8 and Young mania rating scale score lower than 6) for at least 3 months before both evaluations. At the end of follow-up, psychosocial functioning was also evaluated by means of the Functioning Assessment Short Test.


Repeated-measures multivariate analysis of covariance showed that there were main effects of group in the executive domain, in the inhibition domain, in the processing speed domain, and in the verbal memory domain (p<0 .04="" along="" among="" and="" between="" clinical="" cognition="" duration="" factors="" functioning="" illness="" impoverished="" longer="" observed="" only="" p="" poorer="" processing="" psychosocial="" related="" relationships="" significantly="" slow="" strong="" the="" time="" to="" was="" were="" whereas="">


Executive functioning, inhibition, processing speed and verbal memory were impaired in euthymic bipolar out-patients. Although cognitive deficits remained stable on average throughout the follow-up, they had enduring negative effects on psychosocial adaptation of patients.
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