Polygenic susceptibility to prostate and breast ... [Br J Cancer. 2011] - PubMed - NCBI
Polygenic susceptibility to prostate and breast cancer: implications for personalised screening.
Source
Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, University Forvie Site, Robinson way, Cambridge CB2 0SR, UK.
np275@medschl.cam.ac.uk
Abstract
BACKGROUND:
We modelled the efficiency of a personalised approach to screening for prostate and breast cancer based on age and polygenic risk-profile compared with the standard approach based on age alone.
METHODS:
We compared the number of cases potentially detectable by screening in a population undergoing personalised screening with a population undergoing screening based on age alone. Polygenic disease risk was assumed to have a log-normal relative risk distribution predicted for the currently known prostate or breast cancer susceptibility variants (N=31 and N=18, respectively).
RESULTS:
Compared with screening men based on age alone (aged 55-79: 10-year absolute risk ≥2%), personalised screening of men age 45-79 at the same risk threshold would result in 16% fewer men being eligible for screening at a cost of 3% fewer screen-detectable cases, but with added benefit of detecting additional cases in younger men at high risk. Similarly, compared with screening women based on age alone (aged 47-79: 10-year absolute risk ≥2.5%), personalised screening of women age 35-79 at the same risk threshold would result in 24% fewer women being eligible for screening at a cost of 14% fewer screen-detectable cases.
CONCLUSION:
Personalised screening approach could improve the efficiency of screening programmes. This has potential implications on informing public health policy on cancer screening.
- PMID:
- 21468051
- [PubMed - indexed for MEDLINE]
- PMCID:
- PMC3093360
Free PMC Article
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