domingo, 5 de agosto de 2012

Surveillance of women at increased risk of brea... [Int J Cancer. 2012] - PubMed - NCBI

Surveillance of women at increased risk of brea... [Int J Cancer. 2012] - PubMed - NCBI

2012 Jul 15;131(2):417-25. doi: 10.1002/ijc.26394. Epub 2011 Oct 20.

Surveillance of women at increased risk of breast cancer using mammography and clinical breast examination: further evidence of benefit.


Genesis Prevention Centre, University Hospital of South Manchester NHS Trust, Wythenshawe, Manchester, United Kingdom.


Women with a significant family history of breast cancer are generally offered early surveillance by mammography and often clinical breast examination (CBE). The evidence base for surveillance has been questioned. We reviewed its effectiveness in terms of tumour size, lymph node status and survival in 7,475 women seen over a 22-year period in the Manchester Family History Clinic. We diagnosed 139 invasive and 26 in situ breast cancers. Seventy-six percent of the invasive cancers were screen detected, 65% node negative and 71% <2 0.0001="0.0001" 18="18" 30="30" 35-50="35-50" 3="3" 50="50" 60="60" a="a" advanced="advanced" age="age" and="and" annual="annual" apart="apart" at="at" be="be" between="between" brca1="brca1" breast="breast" by="by" cancer="cancer" cancers="cancers" carriers="carriers" cbe="cbe" cm="cm" compared="compared" conclude="conclude" contribute="contribute" contributed="contributed" cost="cost" detected="detected" diagnose="diagnose" diagnoses="diagnoses" diagnosis.="diagnosis." diameter="diameter" discovery="discovery" er="er" estimated="estimated" for="for" from="from" grade="grade" have="have" improved="improved" in="in" is="is" less="less" life="life" likely="likely" long-term="long-term" mammographically="mammographically" mammography.="mammography." mammography="mammography" may="may" monthly="monthly" more="more" negative="negative" nine="nine" no="no" node="node" not="not" occult="occult" of="of" outcome="outcome" p="p" per="per" poorer="poorer" positive="positive" quality="quality" responsible="responsible" screening="screening" significantly="significantly" size="size" state="state" status="status" surveillance.="surveillance." survival.="survival." symptomatic="symptomatic" terms="terms" that="that" the="the" to="to" tumours.="tumours." tumours="tumours" twenty-one="twenty-one" was="was" we="we" were="were" with="with" year="year" years="years">Copyright © 2011 UICC.

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