National Guideline Clearinghouse | The role of prophylactic anticonvulsants in the management of brain metastases: a systematic review and evidence-based clinical practice guideline.

Guideline Title

The role of prophylactic anticonvulsants in the management of brain metastases: a systematic review and evidence-based clinical practice guideline.

 

Bibliographic Source(s)

Mikkelsen T, Paleologos NA, Robinson PD, Ammirati M, Andrews DW, Asher AL, Burri SH, Cobbs CS, Gaspar LE, Kondziolka D, Linskey ME, Loeffler JS, McDermott M, Mehta MP, Olson JJ, Patchell RA, Ryken TC, Kalkanis SN. The role of prophylactic anticonvulsants in the management of brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol 2010 Jan;96(1):97-102. [7 references] PubMed

 

Guideline Status

This is the current release of the guideline.

full-text:
National Guideline Clearinghouse The role of prophylactic anticonvulsants in the management of brain metastases: a systematic review and evidence-based clinical practice guideline.

J Neurooncol. 2010 Jan;96(1):97-102. Epub 2009 Dec 3.

The role of prophylactic anticonvulsants in the management of brain metastases: a systematic review and evidence-based clinical practice guideline.

Mikkelsen T, Paleologos NA, Robinson PD, Ammirati M, Andrews DW, Asher AL, Burri SH, Cobbs CS, Gaspar LE, Kondziolka D, Linskey ME, Loeffler JS, McDermott M, Mehta MP, Olson JJ, Patchell RA, Ryken TC, Kalkanis SN.

Source

Department of Neurology, Henry Ford Health System, Detroit, MI, USA.

Abstract

QUESTION:

Do prophylactic anticonvulsants decrease the risk of seizure in patients with metastatic brain tumors compared with no treatment?

TARGET POPULATION:

These recommendations apply to adults with solid brain metastases who have not experienced a seizure due to their metastatic brain disease.

RECOMMENDATION:

Level 3 For adults with brain metastases who have not experienced a seizure due to their metastatic brain disease, routine prophylactic use of anticonvulsants is not recommended. Only a single underpowered randomized controlled trial (RCT), which did not detect a difference in seizure occurrence, provides evidence for decision-making purposes.

PMID:

19957015

[PubMed - indexed for MEDLINE]

PMCID: PMC2808526

Free PMC Article

The role of prophylactic anticonvulsants in the... [J Neurooncol. 2010] - PubMed - NCBI

 

The role of prophylactic anticonvulsants in the management of brain metastases: a systematic review and evidence-based clinical practice guideline