Genetically informed lung cancer medicine. [J Pathol. 2011] - PubMed result

J Pathol. 2011 Jan;223(2):230-40. doi: 10.1002/path.2788. Epub 2010 Oct 25.

Genetically informed lung cancer medicine.
Pao W, Iafrate AJ, Su Z.

Vanderbilt-Ingram Cancer Center, Department of Medicine/Division of Hematology-Oncology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. william.pao@vanderbilt.edu


Abstract
Knowledge of tumour mutation status has become increasingly important for the prioritization of targeted therapies for cancer. We review here the major known 'driver' mutations with therapeutic relevance in non-small cell lung cancer. We also discuss a variety of methods now being employed in molecular diagnostic laboratories to detect genetic alterations in lung tumours. A genetically-informed approach to lung cancer medicine is rapidly becoming the standard of care worldwide and should lead to improved outcomes for patients.

Copyright © 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
PMID: 21125677 [PubMed - indexed for MEDLINE]

Genetically informed lung cancer medicine. [J Pathol. 2011] - PubMed result