sábado, 14 de julio de 2012

Re-emergence and decline of dengue virus seroty... [J Infect Dis. 2012] - PubMed - NCBI

Re-emergence and decline of dengue virus seroty... [J Infect Dis. 2012] - PubMed - NCBI

J Infect Dis. 2012 Jun 27. [Epub ahead of print]

Re-emergence and decline of dengue virus serotype 3 in Puerto Rico.

Source

Centers for Disease Control and Prevention, Division of Vector-borne Infectious Diseases, Dengue Branch, San Juan, Puerto Rico 00920.

Abstract

Background.  The DENV-3 Indian subcontinent strain emerged in Puerto Rico in 1998 after a 21-year absence of this serotype. The rapid expansion of DENV-3 on the island correlated with the withdrawal of the other serotypes for 7 years. DENV-3 prevalence declined in 2008 and remains undetected.Methods. We sequenced complete genomes of 92 DENV-3 clinical isolates to characterize the molecular evolution and phylogeography throughout 10 years of continued sampling (1998-2007).Results. We document eight distinct lineages that emerged simultaneously and evolved independently. Two of the eight lineages were highly associated to transient introductions of foreign viruses, and two of the three endemic lineages covered the entire study period. We found evidence of temporal-geographical clustering only within the three endemic lineages. The phylogeography analysis combined with serotype-specific incidence data showed that transmission of a DENV serotype in a given location and time is usually correlated with the absence of the other serotype.Conclusions. Our study shows the co-transmission of DENV lineages through a complex dissemination pattern dissimilar to the evolutionary dynamics of the other serotypes in the island. High virus genetic diversity and a large naïve population were underlying factors in the expansion of collapse of DENV-3 in Puerto Rico.

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