Association between family history of prostate cancer and positive biopsies in a Brazilian screening program.

Muller RL, Faria EF, Carvalhal GF, Reis RB, Mauad EC, Carvalho AL, Freedland SJ.

Source

Division of Urologic Surgery, Department of Surgery, Duke University Medical Center (DUMC), Box 2626, Durham, NC, 27710, USA, roberto.muller@dm.duke.edu.

Abstract

PURPOSE:

To test the association between family history of prostate cancer (FH) and prostate cancer (PCa) risk in a large screening program in Brazil, as no conclusive study has yet investigated this.

METHODS:

Between 2004 and 2007, 17,569 men were screened in 231 small municipalities using mobile screening units. Positive FH was defined as any relative having PCa among screened men. Men were biopsied if they had digital rectal examination suggestive of PCa or PSA >4.0 ng/mL or PSA of 2.5-4 ng/mL with percent free PSA ≤15 %. We analyzed the association between FH and PCa using multivariable logistic regression in the first screening round of the program.

RESULTS:

Positive FH was present in 735 men (4.2 % of total), and they were younger, better educated and more likely to have had previous PCa screening (41.5 vs. 28.5 %; P < 0.001) compared to men with negative FH. FH status did not affect compliance rates in men recommended to undergo biopsy (P = 0.94). In first round, PCa was detected in 3.1 % of screened men (n = 552). In multivariable analysis, positive FH was associated with increased PCa risk (OR = 1.79; 95 % CI, 1.21-2.65; P = 0.003). However, Gleason scores (P = 0.78) or percent of positive cores (P = 0.32) among men with positive biopsies were similar, regardless of FH status.

CONCLUSIONS:

In Brazil, men with positive FH were at increased PCa risk, which could not be explained by differential biopsy rates. This finding suggests that FH is also a true PCa risk factor in Brazil, a country with highly diverse population in terms of race, ethnicity, culture and socioeconomic status.