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New Variants of Porcine Epidemic Diarrhea Virus, China, 2011 - Vol. 18 No. 8 - August 2012 - Emerging Infectious Disease journal - CDC

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New Variants of Porcine Epidemic Diarrhea Virus, China, 2011 - Vol. 18 No. 8 - August 2012 - Emerging Infectious Disease journal - CDC
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Viruses articles
Volume 18, Number 8–August 2012



Volume 18, Number 8—August 2012

Dispatch

New Variants of Porcine Epidemic Diarrhea Virus, China, 2011

Wentao Li, Heng Li, Yunbo Liu, Yongfei Pan, Feng Deng, Yanhua Song, Xibiao Tang, and Qigai HeComments to Author 
Author affiliations: Huazhong Agricultural University, Wuhan, People’s Republic of China (W. Li, H. Li; F. Deng, X. Tang, Q. He); and Guangdong Wen’s Foodstuffs Group Company, Ltd., Xinxing, People’s Republic of China (Y. Pan, Y. Song)
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Abstract

In 2011, porcine epidemic diarrhea virus (PEDV) infection rates rose substantially in vaccinated swine herds. To determine the distribution profile of PEDV outbreak strains, we sequenced the full-length spike gene from samples from 9 farms where animals exhibited severe diarrhea and mortality rates were high. Three new PEDV variants were identified.
A member of the family Coronaviridae, genus alphacoronavirus, porcine epidemic diarrhea virus (PEDV) is an enveloped, single-stranded positive-sense RNA virus (1). PEDV is the major causative agent of porcine epidemic diarrhea, which is characterized by severe enteritis, vomiting, watery diarrhea, and weight loss. PEDV infections have a substantial detrimental effect on the swine industry because the mortality rates are high, especially in sucking piglets (1). The major structural gene of the 28-kb PEDV genome encodes the multifunctional virulence factor, spike (S), which is responsible for viral receptor binding, induction of neutralizing antibodies, and host cell fusion. The S gene sequences are a distinguishing feature of PEDV strains, which affect virulence and evolution (24).

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