lunes, 17 de enero de 2011

Colorectal Cancer Epigenetics: Complex Simplicity. [J Clin Oncol. 2011] - PubMed result



J Clin Oncol. 2011 Jan 10. [Epub ahead of print]
Colorectal Cancer Epigenetics: Complex Simplicity.

van Engeland M, Derks S, Smits KM, Meijer GA, Herman JG.

GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center; Vrije Universiteit University Medical Center, Amsterdam, the Netherlands; and The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD.


Abstract

Colorectal cancer (CRC) has predominantly been considered a genetic disease, characterized by sequential accumulation of genetic alterations. Growing evidence indicates that epigenetic alterations add an additional layer of complexity to the pathogenesis of CRC, and characterize a subgroup of colorectal cancers with a distinct etiology and prognosis. Epigenetic dysregulation in colorectal cancer is organized at multiple levels, involving DNA methylation, histone modifications, nucleosomal occupancy and remodeling, chromatin looping, and noncoding RNAs. Interactions between these processes and complex associations with genetic alterations have recently been unraveled. It appears that CRC epigenetics will be the paradigm for multistep carcinogenesis, as CRC genetics has been for the past three decades. This review integrates recent data on epigenetic regulation of gene expression in CRC and describes how the understanding of these processes will alter the management of CRC.

PMID: 21220596 [PubMed - as supplied by publisher]
Colorectal Cancer Epigenetics: Complex Simplicity. [J Clin Oncol. 2011] - PubMed result

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