Genome-Wide Association Studies of Cancer. [J Clin Oncol. 2010] - PubMed result

J Clin Oncol. 2010 Jun 28. [Epub ahead of print]

Genome-Wide Association Studies of Cancer.
Stadler ZK, Thom P, Robson ME, Weitzel JN, Kauff ND, Hurley KE, Devlin V, Gold B, Klein RJ, Offit K.

Clinical Genetics Service and the Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, NY, NY; Division of Clinical Cancer Genetics, City of Hope, Duarte, CA; and the Center for Cancer Research, Cancer Inflammation Program, Human Genetics Section, National Cancer Institute-Frederick, Frederick, MD.

Abstract
Knowledge of the inherited risk for cancer is an important component of preventive oncology. In addition to well-established syndromes of cancer predisposition, much remains to be discovered about the genetic variation underlying susceptibility to common malignancies. Increased knowledge about the human genome and advances in genotyping technology have made possible genome-wide association studies (GWAS) of human diseases. These studies have identified many important regions of genetic variation associated with an increased risk for human traits and diseases including cancer. Understanding the principles, major findings, and limitations of GWAS is becoming increasingly important for oncologists as dissemination of genomic risk tests directly to consumers is already occurring through commercial companies. GWAS have contributed to our understanding of the genetic basis of cancer and will shed light on biologic pathways and possible new strategies for targeted prevention. To date, however, the clinical utility of GWAS-derived risk markers remains limited.

PMID: 20585100 [PubMed - as supplied by publisher]

Genome-Wide Association Studies of Cancer. [J Clin Oncol. 2010] - PubMed result