Disrupted brain-immune signaling may help drive neurodegeneration +++

Exhausted T cells can escape tumors and confer long-lasting immunity to cancer in miceExhausted T cells can escape tumors and confer long-lasting immunity to cancer in mice https://www.news-medical.net/news/20260818/Exhausted-T-cells-can-escape-tumors-and-confer-long-lasting-immunity-to-cancer-in-mice.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=alzheimer_s_disease_newsletter_25_august_2026 As the immune system battles cancer, chronic stimulation gradually drives T cells to a state of exhaustion. The perception was that intratumoral T cells expressing LAG3 perform no function: they either just sit there or they die. So, it was both surprising and exciting to see that they can actually drive long-lasting immune memory, a finding that has potential translational implications for LAG3-targeting cancer immunotherapies." Dario A.A. Vignali, senior author, chair and distinguished professor of immunology, University of Pittsburgh School of Medicine Scientists create brain organoids with distinct cortical regional identityScientists create brain organoids with distinct cortical regional identity https://www.news-medical.net/news/20260820/Scientists-create-brain-organoids-with-distinct-cortical-regional-identity.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=alzheimer_s_disease_newsletter_25_august_2026 The human brain is often described as one of the most complex structures in biology, and much of its power comes from how it's organized. Aging shifts memories from vivid details to bigger pictureAging shifts memories from vivid details to bigger picture https://www.news-medical.net/news/20260821/Aging-shifts-memories-from-vivid-details-to-bigger-picture.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=alzheimer_s_disease_newsletter_25_august_2026 Research from the University of East Anglia shows how our memories change with age and why specific details associated with past events can fade over time.