Germline Profiling May Improve Risk Stratification in Therapy-Related Myeloid Neoplasms Edited by Gargi Mukherjee

https://www.medscape.com/viewarticle/germline-profiling-may-improve-risk-stratification-therapy-2026a1000oag?src= Researchers used germline variants to stratify therapy-related myeloid neoplasms (t-MNs) into molecularly and prognostically distinct subgroups beyond treatment-based classifications. They found that germline mutations in cancer predisposition genes identified a high-risk subgroup of t-MNs characterized by complex karyotypes and poor survival. Patients with myeloid-related germline variants or no germline mutations had more favorable outcomes.