Study reveals how p53 mutations cause tumors to resist cancer immunotherapy

https://www.news-medical.net/news/20260722/Study-reveals-how-p53-mutations-cause-tumors-to-resist-cancer-immunotherapy.aspx Immune checkpoint blockade (ICB) therapy has transformed cancer treatment, but many tumors remain resistant. A new study from researchers at the Hackensack Meridian Center for Discovery and Innovation (CDI) identifies a previously unrecognized mechanism by which mutations in the p53 gene can limit the effectiveness of immunotherapy-while also revealing a potential strategy to overcome this resistance.