How researchers are overcoming assay limitations in protein analysis +++

How researchers are overcoming assay limitations in protein analysis The rise of iPSC-derived immune cells and CRISPR-based engineering is reshaping functional genomics, but protein-level validation has struggled to keep pace. https://www.drugdiscoverynews.com/how-researchers-are-overcoming-assay-limitations-in-protein-analysis-17125 The rise of induced pluripotent stem cell (iPSC) technologies has opened new avenues for modeling human biology and probing the mechanisms underlying immune responses. Among the most promising cell types derived from iPSCs are macrophages — versatile, tissue-resident sentinels involved in inflammation, infection, and disease progression. Yet, despite their potential, iPSC-derived macrophages have been notoriously difficult to genetically manipulate and even harder to analyze at the protein level due to their limited numbers and fragile biology. Combination therapy doubles one-year survival in pancreatic cancer trial Findings from the randomized trial suggest that modulating the tumour microenvironment alongside chemotherapy may offer a new strategy for improving outcomes in pancreatic cancer https://www.drugdiscoverynews.com/combination-therapy-doubles-one-year-survival-in-pancreatic-cancer-trial-17121 A drug developed at Northwestern University has shown a promising survival advantage in patients with metastatic pancreatic cancer, a disease that remains among the deadliest solid tumours and is projected to become the second leading cause of cancer-related deaths in the US within the next decade. New initiative expands access to sporadic ALS stem cell models PRISM brings together three organizations to standardize and distribute patient-derived iPSC motor neuron models that better represent the biological diversity of ALS. https://www.drugdiscoverynews.com/new-initiative-expands-access-to-sporadic-als-stem-cell-models-17123 Most drug discovery efforts in amyotrophic lateral sclerosis (ALS) have relied on cell models that represent a narrow slice of the disease. A new collaborative initiative is working to broaden that base.