A New Public Health Threat? ++++ +++ +++ +++ Loneliness Among US Adults: A Growing Concern? Edited by Manasi Talwadekar June 16, 2025

DEFINING THE EPIDEMIC Loneliness: A Public Health Threat? https://www.medscape.com/viewarticle/loneliness-among-us-adults-growing-concern-2025a1000g0i?ecd=mkm_ret_250701_mscpmrk_psych_loneliness_etid7534904&uac=148436CN&impID=7534904 When Doctors Feel Scared, Lonely https://www.medscape.com/viewarticle/going-resident-attending-can-be-scary-lonely-2025a1000d0g?ecd=mkm_ret_250701_mscpmrk_psych_loneliness_etid7534904&uac=148436CN&impID=7534904 A New Vital Sign for Older Adults? https://www.medscape.com/viewarticle/loneliness-isolation-affect-one-third-us-adults-over-50-2025a1000096?ecd=mkm_ret_250701_mscpmrk_psych_loneliness_etid7534904&uac=148436CN&impID=7534904 The Lonely Heart’s ‘Silent Epidemic’ https://www.medscape.com/viewarticle/head-and-heart-managing-silent-epidemic-2025a1000f9y?ecd=mkm_ret_250701_mscpmrk_psych_loneliness_etid7534904&uac=148436CN&impID=7534904 THE UNDERLYING SCIENCE Social Withdrawal Tied to Shifts in Brain Networks https://www.medscape.com/viewarticle/social-withdrawal-aging-tied-shifts-brain-networks-2025a1000f29?ecd=mkm_ret_250701_mscpmrk_psych_loneliness_etid7534904&uac=148436CN&impID=7534904 Digital Technology: Friend or Foe to the Brain? https://www.medscape.com/viewarticle/digital-technology-friend-or-foe-brain-2025a1000ac7?ecd=mkm_ret_250701_mscpmrk_psych_loneliness_etid7534904&uac=148436CN&impID=7534904 How Poor Memory Fuels Loneliness https://www.medscape.com/viewarticle/memory-mood-symptoms-form-feedback-loop-older-adults-2025a10009qe?ecd=mkm_ret_250701_mscpmrk_psych_loneliness_etid7534904&uac=148436CN&impID=7534904 HEALTH OUTCOMES BMI Rise Connected to Loneliness in Vicious Cycle https://www.medscape.com/viewarticle/emotional-eating-weight-gain-mental-issues-vicious-cycle-2025a1000904?ecd=mkm_ret_250701_mscpmrk_psych_loneliness_etid7534904&uac=148436CN&impID=7534904 Living Alone With These Mental Health Issues May Up Suicide Risk https://www.medscape.com/viewarticle/living-alone-depression-anxiety-may-suicide-risk-2025a10008sf?ecd=mkm_ret_250701_mscpmrk_psych_loneliness_etid7534904&uac=148436CN&impID=7534904 Loneliness Linked to Substance Abuse Patterns https://www.medscape.com/viewarticle/six-patterns-define-young-adult-substance-use-united-states-2025a1000c1a?ecd=mkm_ret_250701_mscpmrk_psych_loneliness_etid7534904&uac=148436CN&impID=7534904 US DRUG SPOTLIGHT Olanzapine https://reference.medscape.com/drug/zyprexa-relprevv-olanzapine-342979?ecd=mkm_ret_250701_mscpmrk_psych_loneliness_etid7534904&uac=148436CN&impID=7534904 Risperidone https://reference.medscape.com/drug/perseris-risperdal-consta-risperidone-342986?ecd=mkm_ret_250701_mscpmrk_psych_loneliness_etid7534904&uac=148436CN&impID=7534904 Olanzapine/Samidorphan https://reference.medscape.com/drug/lybalvi-olanzapine-samidorphan-4000059?ecd=mkm_ret_250701_mscpmrk_psych_loneliness_etid7534904&uac=148436CN&impID=7534904