New drug candidate targeting synaptic resilience well tolerated in Alzheimer’s patients ++++

https://www.nia.nih.gov/news/new-drug-candidate-targeting-synaptic-resilience-well-tolerated-alzheimers-patients?&utm_source=nia-eblast&utm_medium=email&utm_campaign=general-20250512 An NIH-funded clinical trial suggests that a new type of drug may be safe for people with Alzheimer’s disease and could potentially mitigate some of the brain damage caused by the condition. Findings from the study support further research to assess the drug’s long-term safety and effectiveness. NIA’s statement on the U.S. Cost of Dementia Model report — A project funded by NIH reported that the total economic burden of Alzheimer’s disease and related dementias will reach $781 billion this year in the U.S. NIA statement on the U.S. Cost of Dementia Model report https://www.nia.nih.gov/news/nia-statement-u-s-cost-dementia-model-report?&utm_source=nia-eblast&utm_medium=email&utm_campaign=general-20250512 Biological clock based on blood measurements predicts mouse lifespan and frailty — Researchers have developed a biological clock based on blood biomarkers that can accurately predict risk of mortality and frailty in mice. The findings lay the foundation for human biological clocks that health care providers can use to better understand how aging impacts patients differently. Biological clock based on blood measurements predicts mouse lifespan and frailty https://www.nia.nih.gov/news/biological-clock-based-blood-measurements-predicts-mouse-lifespan-and-frailty?&utm_source=nia-eblast&utm_medium=email&utm_campaign=general-20250512 A gene guiding brain cell growth may regulate Alzheimer’s plaque size and toxicity — An NIH-funded study suggests that the gene PLXNB1 affects the size and toxicity of beta-amyloid plaques by regulating how glial cells form netlike structures around these proteins. The findings may offer new directions for developing treatments that help clear plaques and reduce harmful brain inflammation. A gene guiding brain cell growth may regulate Alzheimer’s plaque size and toxicity https://www.nia.nih.gov/news/gene-guiding-brain-cell-growth-may-regulate-alzheimers-plaque-size-and-toxicity?&utm_source=nia-eblast&utm_medium=email&utm_campaign=general-20250512