Features of H5N1 Influenza Viruses in Dairy Cows May Facilitate Infection, Transmission in Mammals H5N1 Virus Did Not Efficiently Transmit via Respiratory Route to Ferrets July 8, 2024

https://www.niaid.nih.gov/news-events/features-h5n1-influenza-viruses-dairy-cows-may-facilitate-infection-transmission?utm_campaign=+61309421&utm_content=&utm_medium=email&utm_source=govdelivery&utm_term= A series of experiments with highly pathogenic H5N1 avian influenza (HPAI H5N1) viruses circulating in infected U.S. dairy cattle found that viruses derived from lactating dairy cattle induced severe disease in mice and ferrets when administered via intranasal inoculation. The virus from the H5N1-infected cows bound to both avian (bird) and human-type cellular receptors, but, importantly, did not transmit efficiently among ferrets exposed via respiratory droplets. The findings, published in Nature, suggest that bovine (cow) HPAI H5N1 viruses may differ from previous HPAI H5N1 viruses and that these viruses may possess features that could facilitate infection and transmission among mammals. However, they currently do not appear capable of efficient respiratory transmission between animals or people.