The T cell responses in COVID-19 recovered individuals
A recent study demonstrates that functional CD4+ and CD8+ T cells specifically targeting the entire proteome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain active in individuals who have recovered from severe or mild coronavirus disease 2019 (COVID-19). Moreover, the magnitude of T cell response is correlated with the antibody response. The study is published in the journal Nature Immunology.
In the human immune system, CD4+ and CD8+ T cells play essential roles in subsiding acute pathogenic infection and triggering adaptive immune responses against reinfection. For the effective development of immunotherapies or vaccines against SARS-CoV-2, it is vital to determine the specificity, robustness, and durability of T cells developed following viral infection.
In the current study, the scientists utilized interferon-γ-based assays with peptides spanning multiple regions of SARS-CoV-2 to characterize circulating CD4+ and CD8+ T cells explicitly developed against SARS-CoV-2 in individuals who have recovered from severe or mild COVID-19.
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