Prevention of migraine with monoclonal antibodies against CGRP or the CGRP receptor | Neurological Research and Practice | Full Text

Prevention of migraine with monoclonal antibodies against CGRP or the CGRP receptor | Neurological Research and Practice | Full Text

Prevention of migraine with monoclonal antibodies against CGRP or the CGRP receptor

Addition to the S1 guideline: Therapy of migraine attacks and prevention of migraine. Recommendations of the Germany Society of Neurology and the German Migraine and Headache Society

• Hans-Christoph Diener, 
• Stefanie Förderreuther, 
• Charly Gaul, 
• Florian Giese, 
• Till Hamann, 
• Dagny Holle-Lee, 
• Tim P. Jürgens, 
• Katharina Kamm, 
• Torsten Kraya, 
• Christian Lampl, 
• Arne May, 
• Uwe Reuter, 
• Armin Scheffler & 
• Peer Tfelt-Hansen 

Neurological Research and Practice volume 2, Article number: 11 (2020) Cite this article

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Abstract

Monoclonal antibodies against the calcitonin gene-related peptide (CGRP) receptor (Erenumab) or against CGRP (Eptinezumab, Fremanezumab, Galcanezumab) are new substances for the preventive treatment of migraine. They represent an extension of the therapeutic options, which already exist in migraine prevention. In randomized, placebo-controlled studies, the efficacy and good tolerability of these specific substances have been demonstrated in patients with episodic and chronic migraine. The following treatment recommendation presents a summary of the pivotal studies. Recommendations are provided for the targeted selection of patients as well as for the evaluation of therapeutic success and the duration of treatment. Finally, possible restrictions on the use of this new substance group are discussed.

This guideline is an abridged and translated version of the guideline published by Diener H-C, May A et al., Prevention of migraine with monoclonal antibodies against CGRP or the CGRP receptor, Supplement to S1 Guideline Therapy of Migraine Attack and Prevention of Migraine, 2019, Deutsche Gesellschaft für Neurologie (eds.), Guidelines for Diagnostics and Therapy in Neurology. A complete version of this guideline can be found on the website of the Deutsche Gesellschaft für Neurologie (www.dgn.org/leitlinien) and the AWMF (Arbeitsgemeinschaft wissenschaftlicher Medizinischer Gesellschaften).

This guideline has been approved by the German Neurological Society (DGN) and the German Migraine and Headache Society (GMHS) and was reviewed by the two societies.