CIENCIASMEDICASNEWS: Prediction of antibody aggregation

viernes, 19 de junio de 2020

Prediction of antibody aggregation

	Antibodies
	The latest antibodies news from News Medical

VHH Antibodies (Nanobodies) Advantages and Limitations

Prediction of antibody aggregation

From machine learning to novel experimental methods, great progress has been made in predicting aggregation of therapeutic monoclonal antibodies. A leading researcher in the field presents the latest results.

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[Webinar] Novel p-tau181 Blood Immunoassay; Future of Alzheimer's Disease Research

The p-tau181 assay can distinguish between Alzheimer’s disease and similar conditions by measuring p-tau181 in blood and can demonstrate disease progression over time. The ultrasensitive detection capabilities of Simoa support these critical advances in Alzheimer’s disease research and can aid in the development of innovative disease management strategies.

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SARS-CoV2 Compound Screening and Neutralization Assays

Evaluate key compounds for neutralization potential against the highly pathogenic SARS-CoV-2. Unlock pseudovirus-based infection assays and services and allow for rapid screening of antibodies and entry inhibitors. Utilize innovative cell lines, lentiviruses, assay kits, and antibodies to enable a wide range of preclinical activities for investigating potential COVID-19 antiviral drugs.

	Monoclonal antibody therapy achieves modest reduction in recurrence for patients with HER2-positive DCIS The addition of the monoclonal antibody therapy Trastuzumab to radiotherapy did not reach the protocol objective of a 36% reduction in the ipsilateral breast tumor recurrence rate for women with HER2-positive ductal carcinoma in situ (DCIS) on the NRG Oncology clinical trial NSABP B-43.

	New technique for fast, easy optimization of antibodies using chicken cells Antibodies for potential use as medicines can be made rapidly in chicken cells grown in laboratories. Researchers refer to their technique as the human ADLib system, short for autonomously diversifying libraries.

	Portable analyzer rapidly detects anti-virus antibody in blood serum Researchers have succeeded in detecting anti-avian influenza virus antibody in blood serum within 20 minutes, using a portable analyzer they have developed to conduct rapid on-site bio tests. If a suitable reagent is developed, this technology could be used to detect antibodies against SARS-CoV-2, the causative virus of COVID-19.