IPSE infiltrates nuclei through clathrin-mediated endocytosis | Children's National

IPSE infiltrates nuclei through clathrin-mediated endocytosis | Children's National

IPSE infiltrates nuclei through clathrin-mediated endocytosis IPSE, a protein excreted by the parasite Schistosoma mansoni, infiltrates the nuclei of urothelial cells through clathrin-mediated endocytosis (a process by which cells absorb metabolites, hormones and proteins). Once inside the nucleus, IPSE modulates gene expression, increasing cell proliferation and angiogenesis.