miércoles, 4 de marzo de 2020

Clinical Trial Spotlight: Searching for effective therapies for malignant peripheral nerve sheath tumors | Children's National

Clinical Trial Spotlight: Searching for effective therapies for malignant peripheral nerve sheath tumors | Children's National

Advances in Oncology from Children's National

Malignant peripheral nerve sheath tumors



Effective therapies for malignant peripheral nerve sheath tumors

In an upcoming clinical trial, AeRang Kim, M.D., Ph.D., and colleagues at four other institutions will give participants a combination of drugs that target specific pathways involved in malignant peripheral nerve sheath tumor (MPNST) growth to see if the drugs shrink, slow down or stop the progress of MPNSTs.
Based on preclinical data demonstrating substantial MPNST shrinkage in mice treated with a combination of MEK and mTOR inhibitors, the trial will look at the MEK inhibitor selumetinib in combination with the mTOR inhibitor sirolimus for patients with unresectable or metastatic MPNST.

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