Different doses of galcanezumab versus placebo in patients with migraine and cluster headache: a meta-analysis of randomized controlled trials
Galcanezumab is a novel monoclonal antibody that target to calcitonin gene-related peptide (CGRP). It has been tested for the preventive treatment of migraine and episodic cluster headache by multiple randomiz...The Journal of Headache and Pain 2020 21:14Genetic variants in migraine: a field synopsis and systematic re-analysis of meta-analyses
Numerous genetic variants from meta-analyses of observational studies and GWAS were reported to be associated with migraine susceptibility. However, due to the random errors in meta-analyses, the noteworthines...The Journal of Headache and Pain 2020 21:13Exploring naturally occurring clinical subgroups of post-traumatic headache
To explore naturally occurring clinical subgroups of post-traumatic headache.The Journal of Headache and Pain 2020 21:12The prevalence of primary headache disorders in Saudi Arabia: a cross-sectional population-based study
The large geographical gaps in our knowledge of the prevalence and burden of headache disorders include most of Eastern Mediterranean Region (EMR). Following a nationwide population-based study in Pakistan, we...The Journal of Headache and Pain 2020 21:11The distribution of oxytocin and the oxytocin receptor in rat brain: relation to regions active in migraine
Recent work, both clinical and experimental, suggests that the hypothalamic hormone oxytocin (OT) and its receptor (OTR) may be involved in migraine pathophysiology.The Journal of Headache and Pain 2020 21:10Excess abdominal fat is associated with cutaneous allodynia in individuals with migraine: a prospective cohort study
To investigate the specific relationship between cutaneous allodynia (CA) and the percentages of body fat (BF) and abdominal fat in migraineurs. Additionally, we compared serum levels of inflammatory biomarker...The Journal of Headache and Pain 2020 21:9Burden of migraine in Finland: multimorbidity and phenotypic disease networks in occupational healthcare
Migraine is a complex neurological disorder with high co-existing morbidity burden. The aim of our study was to examine the overall morbidity and phenotypic diseasome for migraine among people of working age u...The Journal of Headache and Pain 2020 21:8- The Journal of Headache and Pain 2020 21:7
Dural arteriovenous fistulas and headache features: an observational study
Dural arteriovenous fistulas are intracranial vascular malformations, fed by dural arteries and draining venous sinuses or meningeal veins. Clinical course varies widely and ranges from benign with spontaneous...The Journal of Headache and Pain 2020 21:6Prevalence and risk factors associated with headache amongst medical staff in South China
A previous study by our team reported the prevalence of primary headache disorders and factors associated with headache among nurses in three hospitals in North China. The aim of this cross-sectional survey wa...The Journal of Headache and Pain 2020 21:5Microglia P2X4R-BDNF signalling contributes to central sensitization in a recurrent nitroglycerin-induced chronic migraine model
According to our previous study, microglia P2X4 receptors (P2X4Rs) play a pivotal role in the central sensitization of chronic migraine (CM). However, the molecular mechanism that underlies the crosstalk betwe...The Journal of Headache and Pain 2020 21:4The epidemiology of headaches among patients with epilepsy: a systematic review and meta-analysis
Headache is the symptom of pain in the face, head or neck that causes disability in most people with medical and neurological disorders. It frequently co-occurs with most chronic diseases such as epilepsy and ...The Journal of Headache and Pain 2020 21:3ICHD-3 is significantly more specific than ICHD-3 beta for diagnosis of migraine with aura and with typical aura
In the emergency room, distinguishing between a migraine with aura and a transient ischemic attack (TIA) is often not straightforward and mistakes can be harmful to both the patient and to society. To account ...The Journal of Headache and Pain 2020 21:2White matter changes in chronic and episodic migraine: a diffusion tensor imaging study
White matter alterations have been observed in patients with migraine. However, no microstructural white matter alterations have been found particularly in episodic or chronic migraine patients, and there is l...The Journal of Headache and Pain 2020 21:1Cost of chronic and episodic migraine patients in continuous treatment for two years in a tertiary level headache Centre
Migraine is one of the most common neurological diseases and an estimated 1.04 billion people worldwide have been diagnosed with migraine. Available data suggest that migraine is world widely associated with a...The Journal of Headache and Pain 2019 20:120The crossover design for migraine preventives: an analyses of four randomized placebo-controlled trials
To evaluate the crossover design in migraine preventive treatment trials by assessing dropout rate, and potential period and carryover effect in four placebo-controlled randomized controlled trials (RCTs).The Journal of Headache and Pain 2019 20:119Correction to: Galcanezumab in episodic migraine: subgroup analyses of efficacy by high versus low frequency of migraine headaches in phase 3 studies (EVOLVE-1 & EVOLVE-2)
After publication of our article [1] we were notified that the data presented in the upper row of Fig. 7 was inadvertently the least square mean change from baseline (standard error) at Month 6 rather than the...The Journal of Headache and Pain 2019 20:118The original article was published in The Journal of Headache and Pain 2019 20:75Mechanisms of migraine as a chronic evolutive condition
Understanding the mechanisms of migraine remains challenging as migraine is not a static disorder, and even in its episodic form migraine remains an “evolutive” chronic condition. Considerable progress has bee...The Journal of Headache and Pain 2019 20:117Impaired intrinsic functional connectivity between the thalamus and visual cortex in migraine without aura
Resting-state functional magnetic resonance imaging (fMRI) has confirmed disrupted visual network connectivity in migraine without aura (MwoA). The thalamus plays a pivotal role in a number of pain conditions,...The Journal of Headache and Pain 2019 20:116TRPM8 genetic variant is associated with chronic migraine and allodynia
Many single nucleotide polymorphisms (SNPs) have been reported to be associated with migraine susceptibility. However, evidences for their associations with migraine endophenotypes or subtypes are scarce. We a...The Journal of Headache and Pain 2019 20:115Primary headache disorders among the adult population of Mongolia: prevalences and associations from a population-based survey
In the ongoing Global Campaign endeavour to improve knowledge and awareness of headache prevalence worldwide, Mongolia is a country of interest. It sits between Russia and China, in which prevalence is, respec...The Journal of Headache and Pain 2019 20:114Consensus of the Hellenic Headache Society on the diagnosis and treatment of migraine
More than 0.6 million people suffer from disabling migraines in Greece causing a dramatic work loss, but only a small proportion of migraineurs attend headache centres, most of them being treated by non-expert...The Journal of Headache and Pain 2019 20:113- The Journal of Headache and Pain 2019 20(Suppl 1):109This article is part of a Supplement: Volume 20 Supplement 1
Alterations of individual thalamic nuclei volumes in patients with migraine
The aim of this study is to investigate the alterations of thalamic nuclei volumes and the intrinsic thalamic network in patients with migraine.The Journal of Headache and Pain 2019 20:112Prevalence, burden, and clinical management of migraine in China, Japan, and South Korea: a comprehensive review of the literature
The objective of this review was to determine the unmet needs for migraine in East Asian adults and children.The Journal of Headache and Pain 2019 20:111Cortical GABA in migraine with aura -an ultrashort echo magnetic resonance spectroscopy study
The aim of this cross-sectional study was to investigate the cortical metabolite concentrations in patients suffering from migraine with aura (MWA). We hypothesized that occipital γ-aminobutyric acid (GABA) le...The Journal of Headache and Pain 2019 20:110Functional connectivity studies in migraine: what have we learned?
Resting-state functional connectivity (FC) MRI has widely been used to understand migraine pathophysiology and to identify an imaging marker of the disorder. Here, we review what we have learned from FC studies.The Journal of Headache and Pain 2019 20:108Late sodium current blocker GS967 inhibits persistent currents induced by familial hemiplegic migraine type 3 mutations of the SCN1A gene
Familial hemiplegic migraine (FHM) is a group of genetic migraine, associated with hemiparesis and aura. Three causative different genes have been identified, all of which are involved in membrane ion transpor...The Journal of Headache and Pain 2019 20:107Association of diet and headache
The global prevalence of migraine as a primary headache has been estimated as 14.4% in both sexes. Migraine headache has been ranked as the highest contributor to disability in under 50 years old population in...The Journal of Headache and Pain 2019 20:106C-fibers may modulate adjacent Aδ-fibers through axon-axon CGRP signaling at nodes of Ranvier in the trigeminal system
Monoclonal antibodies (mAbs) towards CGRP or the CGRP receptor show good prophylactic antimigraine efficacy. However, their site of action is still elusive. Due to lack of passage of mAbs across the blood-brai...The Journal of Headache and Pain 2019 20:105Altered functional connectivity of the red nucleus and substantia nigra in migraine without aura
Functional connectivity (FC) has been used to investigate the pathophysiology of migraine. Accumulating evidence is pointing toward malfunctioning of brainstem structures, i.e., the red nucleus (RN) and substa...The Journal of Headache and Pain 2019 20:104Reduced resting-state brain functional network connectivity and poor regional homogeneity in patients with CADASIL
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) manifests principally as a suite of cognitive impairments, particularly in the executive domain. Executive f...The Journal of Headache and Pain 2019 20:103Burden of headache disorders in China, 1990–2017: findings from the Global Burden of Disease Study 2017
Headache has emerged as a global public health concern. However, little is known about the burden from headache disorders in China. The aim of this work was to quantify the spatial patterns and temporal trends...The Journal of Headache and Pain 2019 20:102Prevalence and burden of headache in children and adolescents in Austria – a nationwide study in a representative sample of pupils aged 10–18 years
Headache disorders are highly prevalent worldwide, but not so well investigated in children and adolescents as in adults: few studies have included representative nationwide samples. No data exist for Austria ...The Journal of Headache and Pain 2019 20:101Headaches in the emergency department –a survey of patients’ characteristics, facts and needs
Headache is very often the cause for seeking an emergency department (ED). However, less is known about the different diagnosis of headache disorders in the ED, their management and treatment. The aim of this ...The Journal of Headache and Pain 2019 20:100The appropriate dosing of erenumab for migraine prevention after multiple preventive treatment failures: a critical appraisal
Erenumab, a fully human monoclonal antibody directed against the calcitonin gene-related peptide receptor, was approved for the prevention of episodic (EM) or chronic migraine (CM) at the monthly dose of 70 mg...The Journal of Headache and Pain 2019 20:99Acute and preventive pharmacological treatment of post-traumatic headache: a systematic review
Post-traumatic headache (PTH) is associated with considerable disability and reduced health-related quality of life. Despite the very high prevalence of PTH, there are no evidence-based guidelines for PTH trea...The Journal of Headache and Pain 2019 20:98New diagnostic criteria for headache attributed to transient ischemic attacks
The International Classification of Headache Disorders diagnostic criteria for Headache Attributed to Transient Ischemic Attack (TIA) and many other secondary headaches are based primarily on the opinion of ex...The Journal of Headache and Pain 2019 20:97Differences in treatment response between migraine with aura and migraine without aura: lessons from clinical practice and RCTs
Migraine is a major public health problem afflicting approximately 10% of the general population and is a leading cause of disability worldwide, yet our understanding of the basis mechanisms of migraine remain...The Journal of Headache and Pain 2019 20:96Identifying menstrual migraine– improving the diagnostic criteria using a statistical method
To develop a robust statistical tool for the diagnosis of menstrually related migraine.The Journal of Headache and Pain 2019 20:95Aura and Head pain: relationship and gaps in the translational models
Migraine is a complex brain disorder and initiating events for acute attacks still remain unclear. It seems difficult to explain the development of migraine headache with one mechanism and/or a single anatomic...The Journal of Headache and Pain 2019 20:94Structural changes of cerebellum and brainstem in migraine without aura
Increasing evidence has suggested that the cerebellum is associated with pain and migraine. In addition, the descending pain system of the brainstem is the major site of trigeminal pain processing and modulati...The Journal of Headache and Pain 2019 20:93Current and emerging evidence-based treatment options in chronic migraine: a narrative review
Chronic migraine is a disabling condition that is currently underdiagnosed and undertreated. In this narrative review, we discuss the future of chronic migraine management in relation to recent progress in evi...The Journal of Headache and Pain 2019 20:92Animal models of migraine and experimental techniques used to examine trigeminal sensory processing
Migraine is a common debilitating condition whose main attributes are severe recurrent headaches with accompanying sensitivity to light and sound, nausea and vomiting. Migraine-related pain is a major cause of...The Journal of Headache and Pain 2019 20:91Lasmiditan for acute treatment of migraine in patients with cardiovascular risk factors: post-hoc analysis of pooled results from 2 randomized, double-blind, placebo-controlled, phase 3 trials
In addition to the increased risk for cardiovascular (CV) disease and CV events associated with migraine, patients with migraine can also present with a number of CV risk factors (CVRFs). Existing treatment op...The Journal of Headache and Pain 2019 20:90Identifying and managing refractory migraine: barriers and opportunities?
The term refractory migraine has been used to describe persistent headache that is difficult to treat or fails to respond to standard and/or aggressive treatments. This subgroup of migraine patients are genera...The Journal of Headache and Pain 2019 20:89Migraine patients’ journey until a tertiary headache center: an observational study
Migraine diagnosis is based on clinical aspects and is dependent on the experience of the attending physician. This study aimed to describe the patients journey profile until they start their experience in a t...The Journal of Headache and Pain 2019 20:88Electrical stimulation of the superior sagittal sinus suppresses A-type K+ currents and increases P/Q- and T-type Ca2+ currents in rat trigeminal ganglion neurons
Migraine is a debilitating neurological disorder involving abnormal trigeminovascular activation and sensitization. However, the underlying cellular and molecular mechanisms remain unclear.The Journal of Headache and Pain 2019 20:87Shortcomings and missed potentials in the management of migraine patients - experiences from a specialized tertiary care center
Migraine is a common and severely disabling neurological disorder affecting millions of patients in Europe. Despite the availability of evidence-based national and international guidelines, the management of m...The Journal of Headache and Pain 2019 20:86Migraine: a major debilitating chronic non-communicable disease in Brazil, evidence from two national surveys
Even though migraine and other primary headache disorders are common and debilitating, major health surveys in Brazil have not included them. We repair this omission by combining data on non-communicable disea...The Journal of Headache and Pain 2019 20:85
miércoles, 12 de febrero de 2020
The Journal of Headache and Pain | Articles
The Journal of Headache and Pain | Articles
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