Plasma neurofilament light in progressive multiple sclerosis.

Author information

1: Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
2: Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
3: Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.
4: UK Dementia Research Institute at UCL, London, UK.

Abstract

Neurofilaments (Nfs) are a family of neuronal intermediate filaments involved in the growth and stability of axons, and, through incorporation into different supramolecular assemblies, also in synaptic organization and function in the central nervous system. Pioneering work by Lars Rosengren and colleagues in the late 1980s led to the establishment of an enzyme-linked immunosorbent assay (ELISA) based on polyclonal antisera that allowed for the reliable quantification of the neurofilament light (NfL) subunit in cerebrospinal fluid (CSF).