CIENCIASMEDICASNEWS: Medical News | Medical Articles: What are you missing with MMR by IHC testing alone?

miércoles, 27 de noviembre de 2019

Medical News | Medical Articles: What are you missing with MMR by IHC testing alone?

	Immunology
	The latest immunology news from News Medical

What are you missing with MMR by IHC testing alone?

IHC can miss up to 10% of dMMR tumor samples. Current guidelines recommend co-testing tumor samples using both MSI by PCR and MMR by IHC, decreasing the number of mischaracterized tumor samples to less than 1%

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Using Microplate Shakers in Immunology Research

For both medicine and biology, immunology is an important field. Immunology is the study of diseases resulting from disorders of the immune system. An invading organism, which causes a person or animal to be sick, is attacked by the immune system until they feel better.

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Vaping wrecks immune cell function, increases infection risk

A new study published in the Journal Cell Physiology shows that e-cigarettes have toxic effects on neutrophils function, making them a threat to human health by increasing the likelihood of infection with Gram-negative bacteria.

	Scientists attempt to cure HIV using CRISPR, with varying results Scientists have used the gene-editing technology CRISPR in an attempt to cure a person infected with HIV, with some success. The attempt was successful, but only to a certain extent ̶ the edited cells have survived in the man’s body for more than a year and no side effects were detected. However, there were not enough cells to significantly reduce the amount of HIV in his blood, so the effort fell short of being a cure for the illness.

	Juvenile immune arthritis – new treatments wanted Juvenile immune arthritis (JIA) is a severely undertreated condition, and new medications are badly needed to relieve the signs and symptoms of the illness, according to a new study presented at the 2019 ACR/ARP Annual Meeting.

	Scientists use CAR-T cells to reverse cardiac fibrosis Scientists at the University of Pennsylvania’s Abramson Cancer Center have used CAR-T cells to treat cardiac fibrosis, a key part of heart disease and cardiac arrest. The novel study, which was recently published in Nature, explains how the T cell therapy has been successfully implemented to target and destroy the scar tissue that ultimately leads to heart failure.

	Vaccination against HIV can be counterproductive if it triggers the wrong type of immune response A discovery could help immunologists design vaccines that are more effective in protecting against HIV infection. Several non-human primate studies looking at HIV's relative – SIV – provided evidence that creating too many soft targets can weaken vaccination that would have otherwise protected against infection.