CIENCIASMEDICASNEWS: Medical News | Medical Articles: Using Gene Editing and iPSC Differentiation to Model Neurological Disease

miércoles, 27 de noviembre de 2019

Medical News | Medical Articles: Using Gene Editing and iPSC Differentiation to Model Neurological Disease

	Genetics
	The latest Genetics news from News Medical

Using Gene Editing and iPSC Differentiation to Model Neurological Disease

Induced pluripotent stem cells (iPSCs) and gene-editing technology provide an unparalleled biomedical prospect for disease modeling, development of therapeutic strategies, and high-throughput drug screening for neurological diseases such as Alzheimer’s Huntingdon’s and Parkinson’s.

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			Genetic variations linked to declines in blood oxygen levels during sleep identified Researchers have identified 57 genetic variations of a gene strongly associated with declines in blood oxygen levels during sleep. Low oxygen levels during sleep are a clinical indicator of the severity of sleep apnea, a disorder that increases the risk of heart disease, dementia, and death.

			Breakthrough study suggests ways to develop treatments for rare genetic skin disease A breakthrough has been made in understanding a rare genetic skin disease that causes progressively enlarging skin tumours over the scalp, face and body.

	Hibernators reveal genetic clues to better understand and treat obesity, metabolic disorders Hibernation is one of nature's strangest quirks, inducing bears and other mammals to pack on massive weight- amounts that would be unhealthy for humans-;so they can survive months of slumber. Yet when these animals reemerge, they are as fit as ever.

	Common genetic variant explains why immunotherapy often fails in Crohn's disease The reason why a commonly used range of drugs is not effective in some patients living with Crohn’s disease has so far not been identified. However, a collaboration between the University of Exeter, Royal Devon & Exeter NHS Foundation Trust and the Wellcome Sanger Institute has discovered a genetic marker that could lead to personalized treatments for Crohn’s cases.

	Genetic mutation of APOE gene may provide protection against Alzheimer's disease A team of researchers has identified that a genetic mutation of the APOE gene, the major susceptibility gene for late-onset Alzheimer's disease, may provide protection against the devastating neurological illness.

	Genetic endowment, family dynamics play a large role in athletic development The Journal of Athletic Training, the National Athletic Trainers' Association's scientific publication, released today Early Single Sport Specialization in a High-Achieving U.S. Athlete Population: Comparing National Collegiate Athletic Association Student-Athletes and Undergraduate Students in their special thematic issue focused on youth sport specialization.