domingo, 23 de septiembre de 2018

Psychosocial and behavioral outcomes of genomic testing in cancer: a systematic review. - PubMed - NCBI

Psychosocial and behavioral outcomes of genomic testing in cancer: a systematic review. - PubMed - NCBI



 2018 Sep 11. doi: 10.1038/s41431-018-0257-5. [Epub ahead of print]

Psychosocial and behavioral outcomes of genomic testing in cancer: a systematic review.

Abstract

Psychosocial and behavioral outcomes of genetic testing in oncology are well known, however, it is unclear how these findings will generalize to more complex genomic testing. The aim of this systematic review was to assess the psychosocial and behavioral outcomes of cancer genomic testing. Studies were selected for inclusion if they were published from January 2003 to January 2017 and addressed psychological and behavioral outcomes of cancer genomic testing in adults. A review of four databases identified 9620 abstracts, with 22 publications meeting the inclusion criteria. Of the included articles, 11 studies reported on outcomes of germline testing, with three articles assessing panel testing and eight SNP testing. No studies assessed the outcomes of WGS or WES. Eleven articles assessed the outcomes of somatic testing, including testing for cancer prognosis and for personalized therapies. Studies were biased toward breast cancer and Caucasian women with high education and socioeconomic status. While studies demonstrated limited adverse psychological outcomes associated with genomic testing, a lack of consistency in psychosocial measures precluded any meta-analysis. Changes in health behavior following positive results were limited, and in some cases risk perception was not altered following genomic testing. There is limited evidence of adverse psychosocial outcomes and changes in health behavior following genomic testing to assess cancer risk. Findings from this review highlight the need for longitudinal research with superior methodological and theoretical design.

PMID:
 
30206354
 
DOI:
 
10.1038/s41431-018-0257-5

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