Challenges in neurodegenerative diseases

Edited by Dr Julie Chan

A thematic series in Journal of Biomedical Science.

Review
LRRK 2 gene mutations in the pathophysiology of the ROCO domain and therapeutic targets for Parkinson’s disease: a review
Parkinson’s disease (PD) is the most common movement disorder and manifests as resting tremor, rigidity, bradykinesia, and postural instability. Pathologically, PD is characterized by selective loss of dopamin...
Authors:Meng-Ling Chen and Ruey-Meei Wu
Citation:Journal of Biomedical Science 2018 25:52
Published on: 14 June 2018
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Content Type:Review
The involvement of endoplasmic reticulum formation and protein synthesis efficiency in VCP- and ATL1-related neurological disorders
The endoplasmic reticulum (ER) is the biggest organelle in cells and is involved in versatile cellular processes. Formation and maintenance of ER morphology are regulated by a series of proteins controlling me...
Authors:Yu-Tzu Shih and Yi-Ping Hsueh
Citation:Journal of Biomedical Science 2018 25:2
Published on: 8 January 2018
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Content Type:Review
Roles of sigma-1 receptors on mitochondrial functions relevant to neurodegenerative diseases
The sigma-1 receptor (Sig-1R) is a chaperone that resides mainly at the mitochondrion-associated endoplasmic reticulum (ER) membrane (called the MAMs) and acts as a dynamic pluripotent modulator in living syst...
Authors:Tzu-Yu Weng, Shang-Yi Anne Tsai and Tsung-Ping Su
Citation:Journal of Biomedical Science 2017 24:74
Published on: 16 September 2017
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Content Type:Review
Repositioning drugs for traumatic brain injury - N-acetyl cysteine and Phenserine
Traumatic brain injury (TBI) is one of the most common causes of morbidity and mortality of both young adults of less than 45 years of age and the elderly, and contributes to about 30% of all injury deaths in ...
Authors:Barry J. Hoffer, Chaim G. Pick, Michael E. Hoffer, Robert E. Becker, Yung-Hsiao Chiang and Nigel H. Greig
Citation:Journal of Biomedical Science 2017 24:71
Published on: 9 September 2017
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Content Type:Review
3D brain Organoids derived from pluripotent stem cells: promising experimental models for brain development and neurodegenerative disorders
Three-dimensional (3D) brain organoids derived from human pluripotent stem cells (hPSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), appear to recapitulate the brain’s 3D...
Authors:Chun-Ting Lee, Raphael M. Bendriem, Wells W. Wu and Rong-Fong Shen
Citation:Journal of Biomedical Science 2017 24:59
Published on: 20 August 2017
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