Breast Cancer Research
Cancer stem cell metabolism
Breast Cancer Research201618:55
DOI: 10.1186/s13058-016-0712-6
© Peiris-Pagès et al. 2016
Received: 12 February 2016
Accepted: 25 April 2016
Published: 24 May 2016
Abstract
Cancer is now viewed as a stem cell disease. There is still no consensus on the metabolic characteristics of cancer stem cells, with several studies indicating that they are mainly glycolytic and others pointing instead to mitochondrial metabolism as their principal source of energy. Cancer stem cells also seem to adapt their metabolism to microenvironmental changes by conveniently shifting energy production from one pathway to another, or by acquiring intermediate metabolic phenotypes. Determining the role of cancer stem cell metabolism in carcinogenesis has become a major focus in cancer research, and substantial efforts are conducted towards discovering clinical targets.
Cancer, above all other diseases, has countless secondary causes.But even for cancer, there is only one prime cause …: metabolism.Otto Warburg
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