sábado, 20 de febrero de 2016

Treatment of Mycobacterium abscessus Infection - Volume 22, Number 3—March 2016 - Emerging Infectious Disease journal - CDC

Treatment of Mycobacterium abscessus Infection - Volume 22, Number 3—March 2016 - Emerging Infectious Disease journal - CDC

Volume 22, Number 3—March 2016


Treatment of Mycobacterium abscessus Infection

Shannon A. NovosadComments to Author , Susan E. Beekmann, Philip M. Polgreen, Kate Mackey, Kevin L. Winthrop, and M. abscessus Study Team
Author affiliations: Oregon Health and Science University, Portland, Oregon, USA (S.A. Novosad, K. Mackey, K.L. Winthrop)University of Iowa Carver College of Medicine, Iowa City, Iowa, USA (S.E. Beekmann, P.M. Polgreen)


Mycobacterium abscessus is often resistant to multiple antimicrobial drugs, and data supporting effective drugs or dosing regimens are limited. To better identify treatment approaches and associated toxicities, we collected a series of case reports from the Emerging Infections Network. Side effects were common and often led to changing or discontinuing therapy.
Mycobacterium abscessus infections are challenging to treat because multidrug resistance necessitates prolonged intravenous (IV) therapy and side effects are perceived to be common. For the best chance of pulmonary disease cure, guidelines from the American Thoracic Society/Infectious Diseases Society of America (ATS/IDSA) recommend multidrug macrolide-based therapy based on susceptibility testing results and surgical resection. However, these guidelines also state that there are no drug combinations with proven efficacy (1). Similarly for extrapulmonary disease, macrolide-based treatment regimens based on susceptibility testing results are recommended (1,2). Inducible macrolide resistance in many strains of M. abscessus further complicates treatment (3). Given the lack of evidence-based therapies, we hypothesized that treatment regimens have no clear pattern and that medication changes and toxicities occur frequently.

The Study

The Emerging Infections Network (EIN) gathers information about emerging infectious diseases in North America (4) and is frequently used for case collection. The EIN is funded through a cooperative agreement between the Centers for Disease Control and Prevention and IDSA. To learn more about treatment regimens and associated side effects, during March–December 2013, we asked EIN physician members to report recent cases of M. abscessusvia an emailed electronic data collection form.
A total of 65 cases were reported from 16 states; patient mean age was 53.6 years. Most cases were in white, nonsmoking women. Concurrent conditions included cystic fibrosis (n = 9, 14%), cancer (n = 7, 11%), and chronic obstructive pulmonary disease (n = 6, 9%). Ten (15%) patients had used immunosuppressive medications in the 3 months before diagnosis. Most (36 [55%]) organisms were reported as M. abscessus complex, 27 (42%) as M. abscessus, and 2 (3%) as M. massliense. According to available records, at the time of case report, 55 (85%) patients had started or finished antimicrobial drug therapy.
Of the 65 patients, 41 (63%) had pulmonary M. abscessus infection; 19 isolates were from bronchoalveolar lavage fluid and 16 from >2 sputum samples. Of these 41 patients, 34 (83%) started antimicrobial drug therapy. Among those not starting therapy, 2 opted for monitoring only, 1 died before therapy was started, and 4 had no reason reported. A total of 21 initial medication combinations were reported (Table 1). The most commonly reported medications were IV amikacin (n = 22, 65%) and azithromycin (n = 24, 71%). The most commonly used regimen was IV amikacin, a second IV agent, and a macrolide (n = 15, 44%). Only 5 patients received no IV agents. Twenty-eight (82%) patients required a change in therapy (because of side effects, lack of effectiveness, or need for suppressive regimen); 3 underwent surgical therapy, and 12 stopped therapy (median duration 12 months, interquartile range [IQR] 9–18 months).
Of the 24 patients with extrapulmonary disease (median age 50 years, IQR 42–66 years), most (17 [71%]) had skin or soft tissue infections. Also reported were 2 corneal, 1 peritoneal, 1 catheter-related, and 1 pacemaker pocket infection plus 1 case each of endocarditis and osteomyelitis. Medical therapy had been started by 21 (88%) patients. Reasons for not starting therapy included being lost to follow-up, declining therapy, or being referred for surgery without antimicrobial drugs. The most commonly used agents were IV amikacin (n = 9, 43%), macrolides (n = 18, 86%), and imipenem (n = 7, 33%) (Table 1). Regimens that contained >1 IV agent were administered to 12 (57%) patients; IV amikacin–based regimens with a macrolide and 1 other IV agent were administered to 5 (24%). Change from the initial therapeutic regimen was needed by 14 (67%) patients. Among the 15 patients who stopped therapy, median duration of therapy was 6 months (IQR 4–8 months); 14 (93%) stopped therapy because of improvement or presumed cure. Fourteen (58%) of the 24 patients with extrapulmonary disease underwent surgery.
Side effects were common; 74 side effects were documented among 34 (62%) of 55 patients who received treatment. Most common were nausea/vomiting (n = 17, 31%) and skin changes (n = 11, 20%) (Table 2). When the specific medication causing a side effect was known, it was most commonly amikacin (22 [30%]) or tigecycline (13 [18%]). Of the 9 reported episodes of renal insufficiency, 7 were attributed to amikacin. IV agents were commonly associated with side effects that often required dosage adjustment or discontinuation. Among those receiving amikacin and tigecycline, 51% and 36% of patients, respectively, had to adjust or stop medication because of side effects. Intermittent dosing of amikacin seemed to cause fewer side effects than daily dosing (42% vs. 77%, respectively). Among patients with renal insufficiency attributed to amikacin, 71% were receiving it daily.
Among patients with pulmonary infection, antimicrobial drug therapy was completely discontinued for 4 because of side effects. No patients with extrapulmonary disease completely stopped therapy because of side effects. Overall, >54 medication changes among 30 patients were made because of side effects or intolerance.
At the time of data collection, 8 patients had died: 6 with pulmonary and 2 with extrapulmonary disease. Of these 8 patients, 6 died while receiving therapy (5 pulmonary, 1 extrapulmonary).


Our series showed a wide range of treatment strategies for M. abscessus infection; most consisted of prolonged antimicrobial drug therapy. Side effects were common, and therapy often needed to be changed or stopped. Amikacin, the most commonly used IV agent, was associated with multiple side effects; amikacin therapy was stopped or adjusted for 51% of patients.
Heterogeneity of initial treatment regimens was less among those with pulmonary disease than among those with extrapulmonary disease, but regimens still varied widely. However, despite the guidelines, surgical therapy was uncommon for patients with pulmonary disease; only 3 patients in this series underwent surgery.
In a retrospective analysis of 41 patients with M. abscessus pulmonary disease in South Korea, 18 (43.9%) patients experienced side effects (5). This percentage is lower than what we found (62%), possibly because a large percentage of patients in our series received amikacin or a regimen with >1 IV agent. In our series, tigecycline was used, but often as a secondary agent. A recent study of 52 patients who received tigecycline-containing salvage regimens reported improvement in 60% of patients but side effects (most commonly nausea/vomiting) in 94%; 23% of side effects were directly associated with tigecycline (6). Side effects from tigecycline were also common among patients in our series.
Our study had several limitations, including unknown specific subspecies of M. abscessus. Most isolates were reported as M. abscessus complex (55%) orM. abscessus (42%), and it is unclear if these were ever correctly identified to the subspecies level (such as M. abscessus abscessus). Given increasing evidence regarding varying antimicrobial drug susceptibility patterns of different subspecies, knowing if treatment patterns or side effect profiles differed between subspecies would be helpful. Incomplete information regarding duration of therapy with specific agents limited our ability to report information such as median time to any side effect or a side effect severe enough to require therapy alteration for individual medications. Although we did collect information regarding outcomes, this study was not powered to evaluate outcomes associated with individual regimens or medications. Because only EIN members could submit cases, selection bias is possible. Their treatment practices may differ from those of non-EIN members if members follow ATS/IDSA guidelines more closely.
Our survey revealed that therapeutic regimens for M. abscessus infection vary widely. Side effects are common and often lead to changing or discontinuing therapy. Given these findings and increasing rates of nontuberculous mycobacterial infections (7,8), prospective studies requiring cooperation across multiple centers are needed to better define appropriate treatment regimens that will maximize effectiveness while minimizing side effects.
Dr. Novosad is a medical doctor and Pulmonary/Critical Care Fellow at Oregon Health and Science University. Her research focuses on the epidemiology and natural history of chronic pulmonary infections.


Members of the M. abscessus Study Team: Lilian Abbo, Philip Brachman, Shingo Chihara, Daniel Gluckstein, K. V. Gopalakrishna, Donald R Graham, Alex Granok, R. Gordon Huth, Michael Klevay, James Leggett, Sarah Mooney, David Mushatt, Steven Norris, Lisa Oakley, Brian Petroelje, Hari Polenakovik, Susan Rhee, Kamla Sanasi-Bhola, Paul Southern, Mingquan Suksanong, Gregory Valainis, Mark Wallace, and Regina Won.
This work was supported by a National Institutes of Health training grant (2T32 HL083808-06) to S.A.N. This publication was supported by the Grant or Cooperative Agreement FOA CK11-1102, funded by the Centers for Disease Control and Prevention.


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Suggested citation for this article: Novosad SA, Beekmann SE, Polgreen PM, Mackey K, Winthrop KL; M. abscessus Study Team. Treatment ofMycobacterium abscessus infection. Emerg Infect Dis. 2016 Mar [date cited]. http://dx.doi.org/10.3201/eid2203.150828
DOI: 10.3201/eid2203.150828

1Members of the study team are listed at the end of this article.

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