domingo, 14 de febrero de 2016

Quantifying the utility of single nucleotide polymorphisms to guide colorectal cancer screening. - PubMed - NCBI

Quantifying the utility of single nucleotide polymorphisms to guide colorectal cancer screening. - PubMed - NCBI





 2016 Feb;12(4):503-13. doi: 10.2217/fon.15.303. Epub 2016 Feb 1.

Quantifying the utility of single nucleotide polymorphisms to guide colorectal cancer screening.

Abstract

AIM:

To determine whether single nucleotide polymorphisms (SNPs) can be used to identify people who should be screened for colorectal cancer.

METHODS:

We simulated one million people with and without colorectal cancer based on published SNP allele frequencies and strengths of colorectal cancer association. We estimated 5-year risks of colorectal cancer by number of risk alleles.

RESULTS:

We identified 45 SNPs with an average 1.14-fold increase colorectal cancer risk per allele (range: 1.05-1.53). The colorectal cancer risk for people in the highest quintile of risk alleles was 1.81-times that for the average person.

CONCLUSION:

We have quantified the extent to which known susceptibility SNPs can stratify the population into clinically useful colorectal cancer risk categories.

KEYWORDS:

cancer screening; colorectal cancer; risk prediction; single nucleotide polymorphisms

PMID:
 
26846999
 
[PubMed - in process]

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